Abstract:
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Purpose: We conducted a prospective study to determine whether a limited biopsy approach with contrast-enhanced color Doppler ultrasound (US) targeted biopsy of the prostate could detect cancers as well as gray-scale US guided systematic biopsy with a larger number of biopsy cores.
Methods and Materials: We examined 920 male screening volunteers (total PSA equal or greater than 1.25 ng/mL and free PSA < 18%). Two independent examiners evaluated each subject. One investigator performed contrast-enhanced targeted biopsies (equal or less than 5) into hypervascular regions in the peripheral zone during intravenous infusion of SonoVue (Bracco, Italy). Subsequently, a second examiner performed 10 systematic biopsies of the prostate. Cancer detection rates for the two techniques were compared.
Results: Cancer was detected in 284/920 subjects (31%). Cancer was detected in 230/920 subjects (25%) by contrast-enhanced targeted biopsy, and in 201/920 patients (21%) with systematic biopsy. Cancer was detected with targeted biopsy alone in 83 subjects (9%), and with systematic biopsy alone in 54 subjects (6%). The overall cancer detection rate (by-patient) was significantly better for the targeted biopsy (p = 0.32). The odds ratio for detection of cancer by targeted biopsy versus systematic biopsy was 3.8 (p < 0.001).
Conclusion: Contrast-enhanced color Doppler targeted biopsy significantly improves cancer detection with fewer than half the number of biopsy cores compared with the systematic approach.
Questions about this event email: andrea.klauser@uibk.ac.at
Frauscher MD, F,
Contrast-enhanced Color Doppler Targeted Biopsy Improves Prostate Cancer Detection. Radiological Society of North America 2003 Scientific Assembly and Annual Meeting, November 30 - December 5, 2003 ,Chicago IL.
http://archive.rsna.org/2003/3103280.html
