RSNA 2003 

Abstract Archives of the RSNA, 2003


K20-1035

Fluorescence-enhanced Molecular Imaging towards Breast Cancer Diagnostics

Scientific Papers

Presented on December 3, 2003
Presented as part of K20: Physics (Fluorescent and Bioluminescent Optical Imaging)

Participants

Anuradha Godavarty PhD, PRESENTER: Nothing to Disclose

Abstract: HTML Purpose: Fluorescence-enhanced optical imaging using near-infrared (NIR) light developed for in-vivo molecular targeting and reporting of cancer provides promising opportunities for diagnostic imaging. In this study, we demonstrated fluorescence-enhanced optical tomography using fluorescent contrast agents in large tissue-mimicking breast phantoms in order to facilitate clinical translation. Methods and Materials: Frequency-domain fluorescence measurements were performed using a gain-modulated ICCD (intensified charge-coupled device) detection system for rapid data acquisition and was operated at 100MHz. Micromolar concentrations of fluorescent contrast agent (indocyanine green, ICG) were used in order to enhance the optical contrast between the target and the background. Results: Targets of 0.5 to 1 cc volume located up to 2 cm deep from the phantom surface, and under target:background contrast ratios of 1:0 and 100:1 were tomographically reconstructed. A 1 cc target located 1 cm from the phantom surface was also differentiated from its background phantom based on the lifetime of the fluorescing contrast agents present in the target and background. While nuclear imaging provides diagnostic imaging opportunities, molecular targeting of tumors using low dosages of fluorescent contrast agents could possibly become an alternate approach and more sensitive. Conclusion: An optical imager with a rapid data acquisition system provides robust and accurate measurements, which when combined with tomography may provide clinical application for targeting early stage tumors using fluorescent contrast agents, based on the absorption contrast or lifetime contrast between the target and the background.       Questions about this event email: agodavar@tamu.edu

Cite This Abstract

Godavarty PhD, A, Sevick-Muraca PhD, E, Eppstein PhD, M, Zhang PhD, C, Fluorescence-enhanced Molecular Imaging towards Breast Cancer Diagnostics.  Radiological Society of North America 2003 Scientific Assembly and Annual Meeting, November 30 - December 5, 2003 ,Chicago IL. http://archive.rsna.org/2003/3100972.html