Abstract Archives of the RSNA, 2014
Hui Li, Abstract Co-Author: Nothing to Disclose
Yuan Qu, Abstract Co-Author: Nothing to Disclose
JIE JIANG, Abstract Co-Author: Nothing to Disclose
LINCHUAN ZHANG, Presenter: Nothing to Disclose
To investigate the utility of stretched exponential model with multi b-values DWI in the grading of cervical cancer.
22 female patients with cervical cancer prior to the treatment were recruited and underwent pelvic MR examination in this study. 12 out of 22 patients were diagnosed with stage IIIB cervical cancer and 10 with stage IIB cervical cancer. DWI was acquired on the sagittal plane with 12 b values (0, 20, 50, 100, 200, 400, 800, 1200, 1800, 2500, 3000, 3500, 4000s/mm2). Parametric maps of distributed diffusion coefficient (DDC, a quantification of intravoxel distribution of apparent diffusion coefficients) and the stretching parameter (α, reflects the heterogeneity of intravoxel water diffusion rates) were generated. ROIs encompassed the whole tumor area. Mann-Whitney U-test was performed to determine if there was any statistically significant difference between the two parameters extracted from stage IIIB cervical tumors and those from stage IIB cervical tumors using a P-value level of 0.05.
Mean values of DDC and α showed significantly differences between IIIB cervical cancers and IIB cervical cancers (P<0.05). DDC was significantly higher in IIIB cervical cancers compared to the stage IIB tumor group (P<0.05), which suggested that IIIB cervical cancers contained a lower number of distinct intravoxel proton pools compared to IIB cervical cancers.The α value was significantly lower in IIIB cervical cancer group compared to IIB cervical cancer group.
Stretched exponential model demonstrated capability to differentiate cervical cancer, where the DDC and α value may be the considerable parameters for the grading of cervical cancer.
Stretched exponential model of non-Gaussian analysis is a valuable approach for the grading of cervical cancer.
Evaluation the Stretched Exponential Model of Non-Gaussian Analysis of Diffusion Weighted Imaging in the Grading of Cervical Cancer. Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14016911.html