Koji Yamashita MD,PhD, Presenter: Nothing to Disclose

Takashi Yoshiura MD, PhD, Abstract Co-Author: Nothing to Disclose

Akio Hiwatashi MD, Abstract Co-Author: Nothing to Disclose

Osamu Togao MD, PhD, Abstract Co-Author: Nothing to Disclose

Kazufumi Kikuchi MD, Abstract Co-Author: Nothing to Disclose

Hiroshi Honda MD, Abstract Co-Author: Nothing to Disclose

Nozomu Matsumoto, Abstract Co-Author: Nothing to Disclose

To assess the feasibility of high–resolution three dimensional diffusion–weighted images (HR3D–DWI) / multi–detector row CT (MDCT) images data fusion for surgical planning for cholesteatoma.

A total of 14 patients (M/F= 7/7, age 11 to 72 years, mean 42.5 years) with acquired cholesteatoma underwent preoperative MRI using a 3.0 T clinical unit and an 8-channel head coil. For each subject, HR3D–DWIs were obtained using a turbo field–echo with diffusion–sensitized driven-equilibrium preparation with following parameters: TR/TE = 6.2/3ms, FA = 10°, ETL = 75, b factor = 800s/mm2, voxel size = 1.5×1.5×1.5mm3, NEX = 2, SENSE factor = 2, and acquisition time = 5min19s. These patients also underwent MDCT with a slice thickness of 0.5mm. Fusion of the HR3D–DWIs and MDCT images was performed using a landmark rigid registration method by a board–certified neuroradiologist on a workstation. The location and extent of cholesteatomas on the fused images was compared with the intraoperative findings.

On the fused images, the extent of the cholesteatoma, which was depicted as a conspicuous high intensity lesion could be easily evaluated with background bony structures. In all patients, the location and extent of the cholesteatoma on the fused images corresponded well with the intraoperative findings.

Image fusion between HR3D–DWI and MDCT images is feasible, and provides valuable preoperative information for surgical planning to otorhinolaryngologists.

Our HR 3D–DWI has isotropic voxel dimensions that enables reformation in any arbitrary plane. It makes easier anatomical registration with CT images and leads to advantages of preoperative planning.

Yamashita, K, Yoshiura, T, Hiwatashi, A, Togao, O, Kikuchi, K, Honda, H, Matsumoto, N, High–resolution Three–dimensional Diffusion-weighted MRI/CT Image Data Fusion for Cholesteatoma Surgical Planning: A Feasibility Study.  Radiological Society of North America 2013 Scientific Assembly and Annual Meeting, December 1 - December 6, 2013 ,Chicago IL. http://archive.rsna.org/2013/13019324.html