Sun Yong, Presenter: Nothing to Disclose

Zhang Jie, Abstract Co-Author: Nothing to Disclose

Yan Dong, Abstract Co-Author: Nothing to Disclose

Liu Canli, Abstract Co-Author: Nothing to Disclose

Recent innovations in wide-coverage MDCT scanners and acquisition modes allow for whole-organ perfusion assessments. The purpose of this study was to investigate the clinical utility of CT perfusion performed on a 256-slice scanner operated in extended coverage (spiral jog) mode, for the diagnosis and treatment planning of liver cirrhosis complicated by liver cancer and portal hypertension.  

261 patients (M: 187, F: 74; average age 46 yrs, range 17-75) with liver cirrhosis, underwent perfusion CT (Brilliance iCT, Philips Healthcare), using the spiral jog mode. Scan parameters were 120 kVp, 220 mAs, scan length: 20-30 cm, pitch 0.915, rotation time 0.4 s, table speed 183 mm/s, slice thickness 2 mm, image matrix 512×512, field of view 400 mm, scan cycles 10-12and inter-scan interval of 7.5sec.7radiologists reviewed the Iodine contrast wash-in and wash-out characteristics of the perfusion series to determine the time phase for optimal visualization of the abdominal aorta, hepatic and portal vein. Key imaging findings related to diagnosis and treatment planning were documented. Intra and extra hepatic lesion characteristics were reviewed.

The optimal post contrast injection delay time for visualization of abdominal aorta, portal vein and hepatic vein were 18-21 sec, 37-52 sec, and 73-83 sec respectively. Using image data from the optimal time phase it was possible to analyze the etiological causes of portal hypertension, precisely display the hepatic vein, portal vein, and collateral circulation, as well as lateral vessel distribution, coursing, and origin. Main portal vein pressure and the visualization of hepatic portal vein branches exhibited an inverse relationship, i.e. greater portal vein pressure led to poor presentation of hepatic portal vein branches. There was no statistical difference in liver mass determined on CT perfusion images and actual resection measurements（1451±227g，P﹥0.05）

The broad range of information related to liver microcirculation and hepatic blood vessels obtained from whole-liver CT perfusion make it a useful imaging technique for diagnosis and treatment planning of liver cirrhosis.  

The broad range of clinical information obtained from whole-liver CT perfusion could be useful in establishing reference values for clinical medicine and surgery, interventional therapy planning

Yong, S, Jie, Z, Dong, Y, Canli, L, Clinical Utility of Whole-Liver CT Perfusion Imaging in the Diagnosis and Treatment Planning of Liver Cirrhosis Complicated by Liver Cancer and Portal Hypertension.  Radiological Society of North America 2011 Scientific Assembly and Annual Meeting, November 26 - December 2, 2011 ,Chicago IL. http://archive.rsna.org/2011/11034334.html