Lucio Calandriello, Presenter: Nothing to Disclose

Anna Rita Larici MD, Abstract Co-Author: Nothing to Disclose

Annemilia Del Ciello, Abstract Co-Author: Nothing to Disclose

Michele Amato MD, Abstract Co-Author: Nothing to Disclose

Pierluigi Granone, Abstract Co-Author: Nothing to Disclose

Lorenzo Bonomo MD, Abstract Co-Author: Nothing to Disclose

To prospectively assess the reproducibility of first pass whole tumor perfusion technique with 64-rows CT in patients with NSCLC (non-small cell lung cancer) with maximum diameter up to 8 cm.  

14 Patients (9 male, 5 female), with histologically proven NSCLC, underwent first pass perfusion CT of the whole tumor by using 64-rows scanner. Five lesions were centrally located and nine peripherally. Three lesions were adjacent to the heart, aorta and diaphragm. Two different techniques were used: a cine mode technique for lesions with diameter up to 4 cm and a sequential mode technique for lesions with diameter up to 8 cm. 50 mL of contrast medium @ 5 mL/sec were injected (start delay: 5 sec). After 24 hours each study was repeated to assess reproducibility. One chest radiologist calculated perfusion parameters using a commercial software (Blood Volume: BV, Perfusion: P, Peak Enhancement Intensity: PEI, Time To Peak: TTP). Mean values of differences (Δ) and standard deviations (SD) were assessed (Bland-Altman test).  

High reproducibility was observed for BV and P with both cine-mode technique (-3.3±0.4; -0.6±1.4) and sequential technique (-2.5±5.3; -1.7±5.5). Reproducibility was better for central lesions (-1.2±4.6 for BV; -0.7±0.9 for P) than for the peripheral ones (3.5±5.1 for BV; -1.9±6.3 for P). Good results were also observed for lesions adjacent to structures affected by motion artifacts (-1.9±4.8 for BV; -0.6±2.5 for P).  

First pass whole tumor perfusion techniques performed with 64-rows CT showed high reproducibility in terms of BV and P, regardless of technique used and tumor site.

CT whole tumor first-pass perfusion technique showed a good reproducibility allowing to use it in clinical practice.

Calandriello, L, Larici, A, Del Ciello, A, Amato, M, Granone, P, Bonomo, L, Perfusion with 64-Rows Computed Tomography of Non-Small Cell Lung Cancer (NSCLC): A Reproducibility Study.  Radiological Society of North America 2011 Scientific Assembly and Annual Meeting, November 26 - December 2, 2011 ,Chicago IL. http://archive.rsna.org/2011/11014421.html