BEGOÑA IGUAL MUÑOZ MD, Abstract Co-Author: Nothing to Disclose

Esther Zorio MD,PhD, Abstract Co-Author: Nothing to Disclose

Jordi Estornell MD,PhD, Abstract Co-Author: Nothing to Disclose

Alicia Maceira MD,PhD, Abstract Co-Author: Nothing to Disclose

Fernando Más-Estellés MD, Abstract Co-Author: Nothing to Disclose

Almudena Lucas-Perez MD, Presenter: Nothing to Disclose

Pablo Nogues-Melendez MD, Abstract Co-Author: Nothing to Disclose

Maria Pilar Lopez-Lereu MD, Abstract Co-Author: Nothing to Disclose

Diana Domingo-Valero, Abstract Co-Author: Nothing to Disclose

Biventricular (BVAC) and left dominant (LDAC) forms had recently been included in the spectrum of arrhythmogenic cardiomyopathy (AC). The aim of the study was to describe , using cardiovascular magnetic resonance anatomical characteristics of ventricular involvement as well as late gadolinium enhancement (LGE) in these conditions.

Medical databases and records from the Cardiology Units of 3 hospitals were reviewed in order to obtain data from patients with AC. Diagnosis of right dominant arrythmogenic cardiomyopathy (RDAC) and BVAC were made according to Task Force criteria. LDAC was diagnosed when left ventricular (LV) LGE was present along with positive family history. Confirmation with genetic testing was available in all patients with LDAC.

26 consecutive patients were included (40+16yrs, 16 males). Right ventricular (RV) involvement was present in 19 patients (73%). Among them, 13 patients (50%) had RV volumes over the upper limit of normality and 6 patients (23%) had just mild involvement with wall motion abnormalities and microaneurysms. LV involvement was present in 24 patients (92%) and all of them showed significant LV LGE. LV systolic dysfunction was observed in 15 patients (57 %) and LV dilatation in 3 patients (11%). LGE was more frequent in the inferior, lateral and inferolateral walls (65 and 57 and 61% of patients, respectively) while septum was seldom affected (26% of cases). LGE was mainly subepicardial, in 46% of patients, transmural in 19% of cases and intramyocardial in only 12%.

1)LV involvement is a frequent finding in AC 2)The most frequent abnormal finding  is LV LGE, while the least frequent is LV dilatation  3)LGE was more frequently subepicardial and located in the inferior and inferolateral walls.

 This report highlights  the value  of LV LGE in this clinical setting.

MUÑOZ, B, Zorio, E, Estornell, J, Maceira, A, Más-Estellés, F, Lucas-Perez, A, Nogues-Melendez, P, Lopez-Lereu, M, Domingo-Valero, D, Cardiac Magnetic Resonance in Arrythmogenic Cardiomyopathy: A Multicenter Study.  Radiological Society of North America 2011 Scientific Assembly and Annual Meeting, November 26 - December 2, 2011 ,Chicago IL. http://archive.rsna.org/2011/11003310.html