Debra Brinkmann PhD, Presenter: Research grant, General Electric Company

The ultimate goals of imaging in radiation therapy are: To accurately anatomically delineate and biologically characterize an individual tumor, select an appropriate course of therapy, and to predict tumor response at the earliest possible time. To biologically characterize an individual tumor an imaging modality must be able to capture information about underlying physiology, metabolism, function, and/or its molecular makeup. Kilovoltage x-ray computed tomography (CT) imaging is the current standard modality for image based radiation therapy treatment planning (RTTP) due to its high spatial resolution and fidelity. CT imaging studies are used to define anatomic structures and target volumes from which beam shapes and orientations are planned. When properly calibrated and free of image artifacts, CT images can provide electron-density information for heterogeneity based dose calculations. Other modalities such as magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), single photon emission computed tomography (SPECT), and positron emission tomography (PET) can provide unique target information and may improve overall radiation therapy patient management. Target delineation based on these modalities can significantly modify treatment volumes compared to conventional techniques. Understanding this potential is important for improvement of patient care. Furthermore, understanding image quality limitations and how acquisition parameters can be modified to optimize information obtained with each modality can also have a significant impact on RTTP and delivery. This presentation addresses optimization of CT, MRI, and PET imaging for RTTP, including capabilities of current imaging devices, site specific scan protocols, and incorporation of this data in the planning process. Following the presentation, the audience should be able to describe advantages and limitations of individual imaging modalities and how their use can be optimized for RTTP.

Brinkmann, D, Minicourse: Image Optimization for Radiation Therapy Treatment Planning: CT, MR, and PET Review.  Radiological Society of North America 2006 Scientific Assembly and Annual Meeting, November 26 - December 1, 2006 ,Chicago IL. http://archive.rsna.org/2006/4426285.html