Johannes Grueneisen, Presenter: Nothing to Disclose

Karsten J. Beiderwellen MD, Abstract Co-Author: Nothing to Disclose

Benedikt Michael Schaarschmidt MD, Abstract Co-Author: Nothing to Disclose

Antonia Schulze-Hagen, Abstract Co-Author: Nothing to Disclose

Michael Forsting MD, Abstract Co-Author: Nothing to Disclose

Thomas C. Lauenstein MD, Abstract Co-Author: Nothing to Disclose

Lale Umutlu MD, Abstract Co-Author: Consultant, Bayer AG

To evaluate the diagnostic value of integrated 18F-FDG PET / MRI for whole-body and dedicated FIGO staging of patients with primary cervical cancer

21 patients with histopathologically confirmed cervical cancer underwent a whole body contrast-enhanced 18F-FDG PET / MRI (Biograph mMR, Siemens, Erlangen, Germany; 0.05 mmol/kg BW Dotarem, Guerbet) prior to therapy. Two radiologists separately evaluated the PET/MRI datasets, regarding local tumor spread of primary cervical cancer lesions as well as detection of nodal metastases and classified the results according to the FIGO staging system. Furthermore, SUV and ADC values of primary tumor lesions were analyzed and correlated with prognostic factors of cervical cancer / occurrence of metastasis, grading and FIGO stage. Mann-Whitney-U test was applied to assess statistical significance.

According to histopathological / surgical findings, PET/MRI enabled correct classification of 19 of the 21 patients (90.5 %) according to FIGO staging. 2 of the 21 patients were misclassified as stage IB, while histopathology revealed locally and microscopic infiltrations of the surgical margins involving the vaginal cuff, resulting in stage 2A. All patients with lymph node metastases (n = 8) could be correctly identified based on PET/MRI. Quantitative assessments showed significantly higher SUVmax and lower ADC values for G3 in comparison to G1 and G2 tumors (p < 0.05). Additionally, higher SUVs and lower ADC values could be determined in nodal positive patients with a lack of statistical significance.

Our results underline the high potential of integrated PET/MRI for whole-body and dedicated FIGO staging of patients with primary cervical cancer, offering additional information on prognostic factors.

Integrated PET/MRI may serve as a highly accurate diagnostic tool for dedicated FIGO staging of primary cervical cancer, providing additional prognostic information.

Grueneisen, J, Beiderwellen, K, Schaarschmidt, B, Schulze-Hagen, A, Forsting, M, Lauenstein, T, Umutlu, L, Diagnostic Value of Simultaneous 18F-FDG PET / MRI for Whole-body Staging and Dedicated FIGO Staging of Patients with Primary Cervical Cancer: Preliminary Results.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14045689.html