Abstract Archives of the RSNA, 2014
Emina Talakic MD, Presenter: Nothing to Disclose
Sebastian Tschauner, Abstract Co-Author: Nothing to Disclose
Helmut Schoellnast MD, Abstract Co-Author: Nothing to Disclose
Tillich Manfred, Abstract Co-Author: Nothing to Disclose
To assess the value of diffusion-weighted imaging (DWI) for differentiation between benign and malignant solid testicular tumors.
This retrospective study was IRB approved and the requirement for patient informed consent was waived. A search of the medical databases 2011 / 2012 yielded 25 patients (mean age ± SD, 48 ± 14 yrs; range, 21-76 yrs) who underwent MRI with DWI of the testes for evaluation of a mass which was detected with ultrasound. The mean apparent diffusion coefficient (ADC) and the standard deviation (SD) of the ADC were recorded for each tumor using ROI measurements to assess both, mean ADC of the tumor and heterogeneity of ADC within the tumor. Histopathology or clinical follow-up was used to define the definitive diagnosis. The K-S test and the unpaired t-test were used to assess normal distribution of the values and to compare differences in mean ADC and mean SD of ADC between benign and malignant tumors. A p-value <.05 was considered statistically significant.
Histopathology revealed malignancy in 8 tumors and no evidence of malignancy in 4 tumors. In the remaining 13 tumors, malignancy was ruled out by clinical and imaging follow-up. The mean ADC of benign tumors was 1.54 x 10-3 mm2/sec and the mean ADC of malignant tumors was 1.56 x 10-3 mm2/sec. The mean SD of the ADC was 1.15 for benign and 1.38 x 10-3 mm2/sec for malignant tumors. The differences in means were not statically significant.
Benign and malignant testicular tumors showed similar mean ADC values and SD of ADC values indicating comparable cell density and tissue homogeneities between the tumors. Therefore, DWI may not enable differentiation between benign and malignant testicular tumors.
"Diffusion-weighted (DW) MR imaging is a technique proved to improve tissue characterization and could be used in the detection and characterization of testicular tumors."
Diffusion Weighted Imaging of Testicular Tumors – Is there a Value for Differentiation between Benign and Malignant?. Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14017938.html