Sreeharsha Tirumani MBBS, MD, Presenter: Nothing to Disclose

Akshay Baheti MBBS, MD, Abstract Co-Author: Nothing to Disclose

Mizuki Nishino MD, Abstract Co-Author: Consultant, Bristol-Myers Squibb Company

Katherine Margaret Krajewski MD, Abstract Co-Author: Research Grant, General Electric Company Spouse, Employee, Ironwood Pharmaceuticals, Inc

Michael Hayden Rosenthal MD, PhD, Abstract Co-Author: Nothing to Disclose

Nikhil H. Ramaiya MD, Abstract Co-Author: Nothing to Disclose

In the era of precision medicine, molecular targeted therapy (MTT)-specific personalized templates can aid radiologists in interpreting restaging scans 1. Anti-VEGF MTTs require knowledge of cancer-specific treatment response criteria (TRC) & class-specific toxicities 2. MTTs which act on targets beyond VEGF axis are associated with drug-specific toxicities. 3. Immunomodulators require familiarity with immune-related response criteria & immune-related adverse events 4. Checklist for chest imaging - subcutaneous edema (imatinib), pleural effusion (dasatinib), pneumonitis (m-TOR inhibitors), tumor cavitation (anti-VEGF MTT), pulmonary embolism (anti-VEGF MTT) 5. Checklist for abdominal imaging - decrease in tumor density (tyrosine kinase inhibitor (TKI)), pseudoprogression  (immunotherapy), intratumoral hemorrhage (TKI), hepatic steatosis (TKI), hepatitis (ipilimumab), vascular thrombosis (TKI), cholecystitis (m-TOR inhibitors), pancreatitis (TKI), bowel complications (anti-VEGF MTT, ipilimumab)

1. Introduce the concept of personalized tumor reporting templates in cancer imaging 2. Discuss anti-VEGF MTTs, MTTs that act beyond VEGF axis and immunomodulators with emphasis on alternate TRC & drug toxicities 3. Illustrate findings which radiologists should look for response assessment  in drug-specific patterns

http://abstract.rsna.org/uploads/2014/14009488/14009488_dvkk.pdf

Tirumani, S, Baheti, A, Nishino, M, Krajewski, K, Rosenthal, M, Ramaiya, N, The Cancer Imaging Radiology Report Template in the Era of Molecular-Targeted Therapy (MTT): What Should Be Included in the Radiology Interpretation and Why.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14009488.html