Mi Hye Yu MD, Presenter: Nothing to Disclose

Jeong-Min Lee MD, Abstract Co-Author: Advisory Board, Bayer AG

Joon Koo Han MD, Abstract Co-Author: Nothing to Disclose

Byung Ihn Choi MD, PhD, Abstract Co-Author: Research Consultant, Samsung Electronics Co Ltd

To determine the value of perfusion parameters from perfusion CT in patients with hepatocellular carcinoma (HCC) and analyze the correlation with those obtained from intravoxel incoherent motion diffusion (IVIM)-diffusion weighted imaging (DWI)

A total of 30 patients (M:F=23:7; mean age, 58.7 ± 13.27; age range, 20-77) suspected having HCC were prospectively enrolled in this study. They underwent IVIM-DWI (10 b values, 1.5T) and liver perfusion CT (4D spiral mode, scan range 10 cm, 21 scans, cycle time 1.5 seconds) within 2 days before hepatic resection. Following perfusion parameters were calculated: blood flow (BF), blood volume (BV), permeability surface (PS), arterial perfusion (AP), portal perfusion (PP), total liver perfusion (TLP) and hepatic perfusion index (HPI) from perfusion CT; apparent diffusion coefficient (ADC), pseudodiffusion coefficient (D*), diffusion coefficient (D) and perfusion fraction (f) from IVIM-DWI. Those parameters statistically analyzed comparing HCC and liver parenchyma. Pearson’s correlation test was also used to correlate perfusion CT and IVIM-DWI parameters.

Regarding the perfusion CT, BF, BV, AP, TLP and HPI were significantly higher, whereas PS and PP were significantly lower in HCC than in the liver parenchyma (BF = 39.46 mL/ 100mL/min, BV = 11.80 ml/100mL, AP = 41.86 mL/min/100mL, TLP = 47.24 mL/min/100mL, HPI = 87.88%, PS = 16.03 ml/100mL/min, PP = 5.37 mL/min/100mL, p < 0.05). Among the IVIM-DWI parameters, D* was significantly lower, whereas f was significantly higher in HCC than in the liver parenchyma (D*, 4.95 vs. 9.71 10-3/mm2/s; f, 20.17 vs. 16.37 %; p < 0.05). However, no significant correlation found between the perfusion CT and IVIM-DWI parameters.

Perfusion CT and IVIM-DWI can quantitatively assess the hepatic perfusion in patients with HCC, even though there was no significant correlation between the parameter of the two modalities.

Quantitative assessment of hepatic perfusion using perfusion CT and IVIM-DWI can provide important information about the hepatic perfusion of HCC.

Yu, M, Lee, J, Han, J, Choi, B, Perfusion CT in Patients with Hepatocellular Carcinoma: Comparison with Intravoxel Incoherent Motion Diffusion (IVIM)-Diffusion Weighted Imaging (DWI).  Radiological Society of North America 2013 Scientific Assembly and Annual Meeting, December 1 - December 6, 2013 ,Chicago IL. http://archive.rsna.org/2013/13024811.html