Maurizo Grosso MD, Presenter: Nothing to Disclose

Liliana Comello, Abstract Co-Author: Nothing to Disclose

Roberto Priotto MD, Abstract Co-Author: Nothing to Disclose

Emanuele Roberto, Abstract Co-Author: Nothing to Disclose

Luca Bertolaccini, Abstract Co-Author: Nothing to Disclose

Alberto Terzi, Abstract Co-Author: Nothing to Disclose

Stephane Chauvie PhD, Abstract Co-Author: Stockholder, Dixit srl

Due to its high prevalence, mortality rate, and easily identifiable at-risk population groups, lung cancer is ideal for early detection programs. We present the baseline results of the SOS study (Studio OSservazionale), a single-arm observational study of chest digital tomosynthesis (DTS) for lung cancer detection in an at-risk population.

Accrual of study participants started in December 2010 and ended in December 2011. Smokers or former smokers aged from 45 to 75 years, with a smoking history of at least 20 pack-years, without malignancy in the 5 years before the start of the study were eligible for the study. DTS were performed at baseline and at 1 year follow up. Subjects with lung nodules were addressed to other radiological examination (CT, contrast enhanced CT or PET/CT).

Of the 1919 candidates assessed, 1843 (96%) were enrolled into the study. The mean age was 61 years (ranging 48-73). A total of 1843 DTS studies were performed. Pulmonary abnormalities were detected in 268 (14.5%) subjects. First-line basal computed tomography (CT) was subsequently carried out in 132 (7.2%) subjects, 68 (4.9%) of which were referred for follow-up CT; PET/CT was performed in 27 (1.46%), and lung cancer was detected in 18 (0.98%) individuals.

The detection rate of non-calcified lung nodules for DTS was comparable to rates reported for CT. A small subgroup underwent low-dose CT and entered a follow-up program. Overall, lung cancer was detected in about 1% of cases. Chest DTS holds promise as a first-line lung cancer screening tool. With a low-dose protocol effective dose could be kept as low 0.1 mSv/exam.

Tomosynthesi could find a role in lung caner screening screening program

Grosso, M, Comello, L, Priotto, R, Roberto, E, Bertolaccini, L, Terzi, A, Chauvie, S, Diagnostic Accuracy of Digital Tomosynthesis of the Chest for Nodules Detection in Lung Cancer Screening Program.  Radiological Society of North America 2013 Scientific Assembly and Annual Meeting, December 1 - December 6, 2013 ,Chicago IL. http://archive.rsna.org/2013/13024341.html