Kevin Kalisz, Presenter: Nothing to Disclose

Edouard Semaan, Abstract Co-Author: Nothing to Disclose

Daniel H. Katz, Abstract Co-Author: Nothing to Disclose

Xiaoming Bi PhD, Abstract Co-Author: Employee, Siemens AG

Marius Cordts, Abstract Co-Author: Employee, Siemens AG

Christoph Guetter PhD, Abstract Co-Author: Employee, Siemens AG

Marie-Pierre Jolly, Abstract Co-Author: Employee, Siemens AG

Benjamin Freed, Abstract Co-Author: Nothing to Disclose

Daniel Lee, Abstract Co-Author: Research funded, CardiacAssist, Inc Spouse, Employee, Takeda Pharmaceutical Company Limited

Preeti Kansal, Abstract Co-Author: Nothing to Disclose

Sanjiv Shah MD, Abstract Co-Author: Research Grant, Gilead Sciences, Inc Research Consultant, United Therapeutics Corporation Research Consultant, DC Devices, Inc Research Consultant, Bayer AG Research Consultant , Bristol-Myers Squibb Company

Michael Markl PhD, Abstract Co-Author: Nothing to Disclose

James Christopher Carr MD, Abstract Co-Author: Speaker, Lantheus Medical Imaging, Inc

Jeremy Douglas Collins MD, Abstract Co-Author: Consultant, C. R. Bard, Inc

To demonstrate the feasibility of strain analysis using deformation field analysis on steady state free precession (SSFP) cardiac MR images with speckle tracking echocardiography (STE) as the reference standard.

44 patients (29 males, average age 52 years) referred to CMR for scar assessment or evaluation of infiltrative disease were imaged on a 1.5T scanner (Magnetom Avanto or Aera, Siemens Healthcare, Erlangen, Germany). Bright blood cine short axis images (TR/TE 42/1.2, FA 79 degrees, frame rate 25, BW 930) were analyzed using prototype software (Siemens Corp., Corporate Technology, Princeton, NJ). Similar to speckle tracking, the spatio-temporal deformation of the LV muscle on cine images was used to derive deformation fields and quantify in-plane strain indices. A subset of images (15 patients) were analyzed again by the first reviewer and independently by a second reviewer. Global peak radial and circumferential strains were compared to values obtained at STE using the Pearson coefficient. The intraclass correlation coefficient (ICC) was used as a measure of inter-observer and intraobserver variability.

CMR peak radial and circumferential strains demonstrated fair and good correlation with STE (r=0.36 and 0.63, respectively). CMR underestimated (p<0.01) the value of peak global radial and circumferential strain compared to STE (-8.8% vs. -23.1% and 18.6% vs 35.5%, respectively). The ICC values for radial and circumferential strain inter- and intraobserver variability were 0.90 and 0.87 and 0.68 and 0.69, respectively.

LV myocardial strain using deformation field analysis on cine SSFP CMR imaging is feasible with excellent and good inter- and intraobserver agreement for radial and circumferential strain respectively. Fair to good agreement was noted between LV global strain by CMR and STE, however. Work is ongoing to determine optimal cine SSFP acquisition parameters, to improve the deformation field algorithm for strain calculation, and to correlate CMR strain values with patient symptoms.

Myocardial strain has been applied to predicting changes in cardiac function is a variety of disease processes. We describe the use of a novel algorithm to compute strain at cinegraphic cardiac MR.

Kalisz, K, Semaan, E, Katz, D, Bi, X, Cordts, M, Guetter, C, Jolly, M, Freed, B, Lee, D, Kansal, P, Shah, S, Markl, M, Carr, J, Collins, J, Left Ventricular Strain Analysis by Cardiac MR Using Deformation Field Analysis at Bright Blood Cine SSFP Imaging: A Comparison with Speckle Tracking Echocardiography.  Radiological Society of North America 2013 Scientific Assembly and Annual Meeting, December 1 - December 6, 2013 ,Chicago IL. http://archive.rsna.org/2013/13020727.html