Jenny Aase Husby MD, Presenter: Nothing to Disclose

Inger Johanne Magnussen, Abstract Co-Author: Nothing to Disclose

Jone Trovik MD, Abstract Co-Author: Nothing to Disclose

Oyvind Salvesen, Abstract Co-Author: Nothing to Disclose

Line Bjorge, Abstract Co-Author: Nothing to Disclose

Helga Salvesen MD, PhD, Abstract Co-Author: Nothing to Disclose

Ingfrid S. Haldorsen MD, Abstract Co-Author: Nothing to Disclose

Explore possible correlations between tumor apparent diffusion coefficient (ADC) values, morphological imaging findings and clinical and histological patient and tumor characteristics in endometrial carcinomas. To investigate interobserver agreement between readers on preoperative staging by MRI, including diffusion weighted imaging (DWI).

In this prospective study, 105 patients with histologically confirmed endometrial carcinoma underwent preoperative conventional MRI including DWI with generation of ADC maps. Three radiologists, blinded to patient data, independently reviewed the images for the presence of deep myometrial invasion, cervical stroma invasion and lymph node metastases, and performed regions of interest (ROI) measurements of ADC values in tumor tissue. Consensus ADC values were analyzed in relation to patient/tumor characteristics, and kappa coefficients (κ) for interobserver agreement on MRI staging results were calculated.

Mean tumor ADC value was significantly lower in tumors with deep myometrial invasion (ADC = 0.75 x 10-3 mm2/s) compared to tumors with superficial or no myometrial invasion (ADC= 0.85 x 10-3 mm2/s; p<0.001). ADC value of the primary tumors was significantly correlated to tumor volume (p=0.007). Mean tumor ADC values measured by the three observers were 0.83, 0.79 and 0.79 x 10-3 mm2/s, respectively. The interobserver agreement for MRI staging was fair to moderate (κ=0.20-0.52) for depth of myometrial invasion, substantial for cervical stroma invasion (κ=0.62-0.72) and moderate to substantial for lymph node metastases (κ=0.46-0.63).

Low tumor ADC value is associated with presence of deep myometrial invasion and the ADC value is negatively correlated to tumor volume in endometrial carcinomas. Preoperative staging by MRI with DWI is prone to considerable interobserver variability. Calculation of tumor ADC values may aid in the prediction of deep myometrial invasion in endometrial carcinomas.

Low tumor ADC value is associated with presence of deep myometrial invasion, and DWI may aid in the prediction of deep myometrial invasion in endometrial carcinomas.

Husby, J, Magnussen, I, Trovik, J, Salvesen, O, Bjorge, L, Salvesen, H, Haldorsen, I, Tumor ADC Value Is Associated with Depth of Myometrial Invasion and Is Negatively Correlated to Tumor Volume in Endometrial Carcinomas.  Radiological Society of North America 2013 Scientific Assembly and Annual Meeting, December 1 - December 6, 2013 ,Chicago IL. http://archive.rsna.org/2013/13016794.html