Isabel Simon-Yarza MD, Presenter: Nothing to Disclose

Guillermo Viteri MD, Abstract Co-Author: Nothing to Disclose

Amaia Garcia-Lallana, Abstract Co-Author: Nothing to Disclose

Iker Anton Ibañez, Abstract Co-Author: Nothing to Disclose

Arlette Elizalde, Abstract Co-Author: Nothing to Disclose

Luis Javier Pina MD, PhD, Abstract Co-Author: Nothing to Disclose

To assess the detection rate of breast cancer using tomosynthesis (TS) as an adjunt tool after normal mammography regarding the ACR density patterns.

This prospective study was performed from October 2011 to March 2012. During this time, 2090 consecutive women and one man (mean age 52.3, range29-88) underwent digital mammography (Inspiration, Siemens, Erlangen, Germany) in a reference center. After the evaluation of the breast density by a radiologist, tomosynthesis (TS) was performed using the oblique mediolateral view in all patients with ACR density patterns 2 (558), 3 (658) and 4 (109). Out of these 1325 patients, 41 were found to have suspicious lesions on conventional mammography (BI-RADS categories 4&5), among them 26 had breast cancer. Thus, 1284 patients with normal or benign mammograms (BI-RADS categories 1 to 3) were included in this study. Statistical analysis was performed to compare the rate of additional cancers detected on TS with regards to the ACR density patterns, calculating a Pearson Chi-square test (SPSS 15.0).

Conventional digital mammography detected 26 cancers (detection rate 1,96%). The use of TS after normal or benign digital mammography detected 6 additional malignant cases (additional detection rate 6/1284: 0.47%): 1 case in ACR 2 (0.08%); 5 cases in dense patterns ACR 3&4 (0,39%). No statistical differences were found between the ACR density patterns (p=0,2).

In our experience, additional TS in oblique mediolateral view after normal mammograms increases the detection rate from 1.96% to 2.42%. Moreover, it can be useful not only in dense patterns (3&4), but also in scattered fibroglandular densities (pattern 2).

TS is an emerging technique that may play an important role to detect additional cancers not seen on mammography, both in dense and in scattered fibroglandular densities breasts.

Simon-Yarza, I, Viteri, G, Garcia-Lallana, A, Anton Ibañez, I, Elizalde, A, Pina, L, The Role of Tomosynthesis after Normal Mammography According to ACR Density Patterns.  Radiological Society of North America 2012 Scientific Assembly and Annual Meeting, November 25 - November 30, 2012 ,Chicago IL. http://archive.rsna.org/2012/12043625.html