Hye Shin Ahn MD, Presenter: Nothing to Disclose

Bo La Yun MD, Abstract Co-Author: Nothing to Disclose

Sun Mi Kim MD, PhD, Abstract Co-Author: Nothing to Disclose

Mijung Jang, Abstract Co-Author: Nothing to Disclose

Mi Sun Kim, Abstract Co-Author: Nothing to Disclose

Chae Yeon Lyou MD, Abstract Co-Author: Nothing to Disclose

Sun Ah Kim MD, Abstract Co-Author: Nothing to Disclose

Soo Chin Kim MD, Abstract Co-Author: Nothing to Disclose

Hye-Young Sun, Abstract Co-Author: Nothing to Disclose

To assess the added value of optical diffusion imaging to ultrasonography(US) in differentiating between benign and malignant breast lesions.

This retrospective study was approved by the institutional review board. Patient informed consent was waived. A total of 145 breast masses (116 benign lesions; 29 cancers) in 145 women (mean age, 46 years; age range, 16-86 years) were included. Five radiologists including two faculty breast radiologists and three third-grade residents independently reviewed US with and without optical diffusion imaging. Each lesion was scored on a scale of 0-100% for suspicion of malignancy, and was rated Breast Imaging Reporting and Data System (BI-RADS) classification. Diagnostic performance was analyzed by comparing values for area under receiver operating characteristic curve (Az). Reader agreement was assessed with intraclass correlation coefficients (ICCs).

Adding optical diffusion imaging, the multireader, multicase ROC analysis revealed improved diagnostic accuracy of US (average area under the ROC curve [Az] = 0.923 for US only, and 0.969 for US with optical diffusion imaging, P= 0.039). The interobserver correlation (ICC) was excellent (0.946 for US and 0.977 for US with optical diffusion imaging). The specificity increased for four readers from an average of 19.5% (22.6 of 116; range, 3.4%–50.9%) to 45.9% (53.2 of 116; range, 11.2%–69.8%) (P < .001 for readers 1, 2, 3,and 4 and P = .238 for reader 5) without a significant change in sensitivity.The readers characterized two additional malignant lesions as BI-RADS 4 or 5 and 153 additional benign lesions as BI-RADS 3 with US and optical diffusion imaging than with US only.

The addition of optical diffusion imaging to US may improve diagnostic performance and markedly decrease false-positive biopsy recommendations.

The use of additional optical diffusion imaging to breast US can decrease false-positive biopsy recommendations and is recommended in the evaluation of breast masses prior to biopsy.

Ahn, H, Yun, B, Kim, S, Jang, M, Kim, M, Lyou, C, Kim, S, Kim, S, Sun, H, Does Adding Optical Diffusion Imaging to US Improve the Differentiation between Benign and Malignant Breast Lesions? Observer Performance Study.  Radiological Society of North America 2012 Scientific Assembly and Annual Meeting, November 25 - November 30, 2012 ,Chicago IL. http://archive.rsna.org/2012/12035361.html