Heinrich Resch MD, Presenter: Nothing to Disclose

Roland Kocijan MD, Abstract Co-Author: Nothing to Disclose

Janina Patsch MD, Abstract Co-Author: Nothing to Disclose

Angela Trubrich MD, Abstract Co-Author: Nothing to Disclose

Christina Bittighofer MD, Abstract Co-Author: Nothing to Disclose

Alexandra Resch MD, Abstract Co-Author: Nothing to Disclose

Franz M. Kainberger MD, Abstract Co-Author: Nothing to Disclose

Osteogenesis Imperfecta (OI) is an inherited disorder characterized by increased bone fragility with recurrent fractures that leads to skeletal deformities in severe cases. Due to the specific pathomorphology bone mineral density is normal, but bone structure is highly deteriorated in the whole skeletal system.

15 patients (12 female, 3 male, mean age 42.8years, range 21 to 52 years) with osteogenesis imperfecta type OI III and IV according to the Sillence classification were investigated. The results were compared to a age correspondent healthy group of females and males. The analysis was performed by a HR-pQCT Scanner (Xtreme CT, SCANCO Medical, Bruetisellen, Switzerland) within the new Research Network of Osteology Vienna (RNO). This network further provides access to several Micro-CT Scanners (VISCOM X8060 NDT X-Ray Inspection System and SCANCO µCT 40). Results were correlated with DXA measurements.

With a spatial resolution of 82 µm and a low radiation exposure of 3 µSv effective dose per 9mm standard slice, the systems provide significant additional information about the bone architecture in osteoporosis and fracture risk. Apart from significant differences in BMD between OI and CO. In particular  we found significant differences in specific BV/TV (Trabecular Bone Volume to Tissue Volume) TB.Sp (trabecular separation) and TB.1/N.SD ( inhomogeneity of the network) derived architectural parameters of the radius and tibia hip between patients with OI and healthy persons.

HR-pQCT is superior to other imaging modalities in displaying the anatomy and architecture of bones and in diagnosing structural abnormalities with higher confidence.in patients with osteogenesis imperfecta

BMD measurements are critical in OI-patients due to the complex deterioration of bone tissue we consider structure analysis by HR-pQCT as an additional helpful tool in clinical management of the disea

Resch, H, Kocijan, R, Patsch, J, Trubrich, A, Bittighofer, C, Resch, A, Kainberger, F, High-Resolution-pQCT in Comparison to BMD Measurements by DXA in Patients with Osteogenesis Imperfecta: Ready for Clinical Use?.  Radiological Society of North America 2011 Scientific Assembly and Annual Meeting, November 26 - December 2, 2011 ,Chicago IL. http://archive.rsna.org/2011/11012929.html