Zhi-Gang Yang, Presenter: Nothing to Disclose

Kun Ying Guo MD, Abstract Co-Author: Nothing to Disclose

Heng Shao, Abstract Co-Author: Nothing to Disclose

To assess the right ventricular (RV) dysfunction and dilatation in patients with mitral regurgitation with sixty-four-slice multidetector row CT (64-MDCT) as compared with cardiac magnetic resonance imaging (MRI) results.

ECG-gated 64-MDCT of the heart was performed in 84 patients (54 had known mitral regurgitation) for the evaluation of RV dysfunction and dilatation. End-diastolic and end-systolic volume, stroke volume, and ejection fraction were measured on 64-MDCT and compared with the results measured on MRI (reference standard). The agreement between 64-MDCT and MRI was tested by using linear regression and Bland-Altman analyses. With receiver operating characteristic analyses, sensitivity and specificity of RV dilatation on 64-MDCT for predicting severity and dysfunction of mitral regurgitation were calculated, respectively.

In patients with and without mitral regurgitation, 64-MDCT measurements resulted in high correlation (r=0.87 to 0.94; all p<0.001) compared with MRI. Good intertechnique agreement was obtained by using linear regression and Bland-Altman analyses. With ROC analyses, RV enlargement (>33mm) on 64-MDCT predicted the RV dysfunction of mitral regurgitation with sensitivity of 92.9% and specificity of 82.9%, respectively.

ECG-gated 64-MDCT provides accurate and reliable assessment of RV function in patients with mitral regurgitation. Moreover, the presence of RV dilatation on the 64-MDCT scan helps predict RV dysfunction and severity of mitral regurgitation.

ECG-gated 64-MDCT was comparable to cardiac MRI in accurately assessing the RV function of patients with and without MR.

Yang, Z, Guo, K, Shao, H, Right Ventricular Dysfunction and Dilatation in Patients with Mitral Regurgitation: Analysis with ECG-gated Sixty-four-slice Multi-detector Row Computed Tomography.  Radiological Society of North America 2011 Scientific Assembly and Annual Meeting, November 26 - December 2, 2011 ,Chicago IL. http://archive.rsna.org/2011/11006560.html