Tae Jin Yun MD, Presenter: Nothing to Disclose

Ji-Hoon Kim MD, Abstract Co-Author: Nothing to Disclose

Seung Hong Choi, Abstract Co-Author: Nothing to Disclose

Chul-Ho Sohn MD, Abstract Co-Author: Nothing to Disclose

Kee Hyun Chang MD, PhD, Abstract Co-Author: Nothing to Disclose

Ji Yeon Jang, Abstract Co-Author: Nothing to Disclose

Yoo-Jeong Yim, Abstract Co-Author: Nothing to Disclose

To evaluate whether apparent diffusion coefficient (ADC) values in diffusion-weighted MR imaging (DWI) with b values of 1000 and 2000 s/mm2 correspond with histopathologic grades in head and neck squamous cell carcinomas.

This retrospective study was approved by the Institutional Review Board. Twenty seven consecutive patients with head and neck squamous cell carcinoma were included in the study. They underwent 1.5 T DWIs with b values of 1000 and 2000 s/mm2 and the carcinomas were histopathologically proven into 14 well differentiated, 7 moderately differentiated, and 6 poorly differentiated carcinomas. Relationships between ADC values and histological grades were investigated using one-way ANOVA, with statistical significance level of .05.

Mean values (standard deviations) of ADC values in each histological grade were as following: well differentiated, 1.18 (0.16) (10-3 mm2/s); moderately differentiated, 1.08 (0.19); and poorly differentiated, 0.77 (0.17) at DWI with b value of 1000s/mm2, and well differentiated, 1.01 (0.13); moderately differentiated, 0.83 (0.15); and poorly differentiated, 0.59 (0.12) at DWI with b value of 2000s/mm2. One way ANOVA testing showed that ADC values at DWI with b value of 1000 s/mm2 were significantly different for the histopathological grades (p=.001). However, no statistically significant difference was found between the ADC values of well differentiated and moderately differentiated carcinomas by Scheffe’s post hoc analysis (P = .554). In terms of ADC values at b value of 2000 s/mm2, one way ANOVA testing showed that ADC values were significantly different for the histological grades (p=.001) and the patients with higher ADC values achieved better histopathological grades by Scheffe’s post hoc analysis.

ADC values in DWI with both b values of 1000 and 2000 s/mm2 correspond with histopathological grades in head and neck squamous cell carcinoma. We postulate that ADC values in DWI with b value of 2000 s/mm2 can be used to predict histopathological grades.

ADC values (b=1000 and b=2000 s/mm2) correspond with histopathological grades and ADC values (b=2000 s/mm2) can be used to predict histopathological grades in the head and neck SqCC.

Yun, T, Kim, J, Choi, S, Sohn, C, Chang, K, Jang, J, Yim, Y, Head and Neck Squamous Cell Carcinoma: Prediction of Histopathological Grades Using Diffusion-weighted MR Imaging with Standard (b=1000 s/mm2) and High (b= 2000 s/mm2) b Values  .  Radiological Society of North America 2010 Scientific Assembly and Annual Meeting, November 28 - December 3, 2010 ,Chicago IL. http://archive.rsna.org/2010/9015131.html