Hiroki Haradome, Presenter: Nothing to Disclose

Luigi Grazioli MD, Abstract Co-Author: Nothing to Disclose

Miles A. Kirchin PhD, Abstract Co-Author: Employee, Bracco Group

Maria Pia Bondioni MD, Abstract Co-Author: Nothing to Disclose

Giovanni Morana MD, Abstract Co-Author: Nothing to Disclose

Rita Tinti MD, Abstract Co-Author: Nothing to Disclose

To compare the imaging findings of different MR liver specific contrast materials (Gd-BOPTA, Gd-EOB-DTPA, Mn-DPDP, and ferumoxides) in the diagnosis of hepatic adenoma (HA) and liver adenomatosis (LA).

44 patients with 156 nodules of either HA or LA were evaluated. MR imaging was performed in all patients before/after Gd-BOPTA, in 15 patients before/after Gd-EOB-DTPA, in 28 patients before/after Mn-DPDP, and in 21 patients before/after ferumoxides. T1wGRE and T2wDP images were acquired as appropriate. Comparison was performed for 156 lesions after Gd-BOPTA, 56 lesions after Gd-EOB-DTPA, 108 lesions after Mn-DPDP, and 74 lesions after ferumoxides.

Pre-contrast T1w and T2w images revealed variable enhancement patterns: 132/156 lesions on precontrast T2w images and 127/156 lesions on precontrast T1w images were either slightly hyperintense or hypointense; the remainder were isointense or not visible. Dynamic evaluation after Gd-BOPTA and Gd-EOB-DTPA revealed homogeneous (149/156) or heterogenous (7/156) hyperintensity in all cases. In the delayed hepatobiliary phase all 156 lesions after Gd-BOPTA and all 56 nodules after Gd-EOB-DTPA appeared hypointense, conversely all 108 HA after Mn-DPDP appeared iso or hyperintense. After ferumoxides administration 56/74 HA showed homogeneous or heterogenous signal drop.

Gd-BOPTA and Gd-EOB-DTPA are more appropriate contrast agents than ferumoxides and Mn-DPDP for the characterization of HA. Dynamic phase imaging provides information on the hypervascular nature. Hypointensity in the hepatobiliary phase after Gd-BOPTA and Gd-EOB-DTPA permits HA to be differentiated from FNH.

Gd-BOPTA and Gd-EOB-DTPA are appropriate contrast agents for the characterization of HA and these hepatobiliary phase allow to be differentiated HA from FNH.

Haradome, H, Grazioli, L, Kirchin, M, Bondioni, M, Morana, G, Tinti, R, The Role of Liver-specific MR Contrast Agents for the Evaluation of Hepatic Adenoma (HA) and Liver Adenomatosis (LA): An Intra-individual Comparison of Imaging and Pathological Findings.  Radiological Society of North America 2009 Scientific Assembly and Annual Meeting, November 29 - December 4, 2009 ,Chicago IL. http://archive.rsna.org/2009/8014921.html