Stephan Metz MD, Presenter: Nothing to Disclose

Carl Ganter MSC, PhD, Abstract Co-Author: Nothing to Disclose

Ernst Josef Rummeny MD, Abstract Co-Author: Nothing to Disclose

Gunnar Brix PhD, Abstract Co-Author: Nothing to Disclose

Markus Schwaiger MD, Abstract Co-Author: Research grant, Siemens AG

Ambros Johannes Beer MD, Abstract Co-Author: Research Funding, Pieris AG, Munich Germany

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) as well as positron emission tomography (PET) of αvβ3-expression and glucose metabolism provide functional and molecular information in addition to tumor morphology, which might be useful for pre-therapeutic stratification and response evaluation to anti-angiogenic therapies. We therefore evaluated the relationship of these three imaging methods in cancer patients.

Twelve patients with primary or metastasized cancer (non small cell lung cancer (NSCLC) n=8; other tumors n=4) were examined with DCE-MRI and PET using [18F]Galacto-RGD and [18F]FDG. From the DCE-MRI data, the area under the initial part of the Gd-DTPA concentration-time curve (IAUGC) as well as the relative blood-volume (rBV) and the relative blood-flow (rBF) were estimated using an open one-compartment model and compared with standardized-uptake-values (SUV’s) from PET imaging by linear-regression-analysis.

No significant correlation could be demonstrated for rBF, rBV and [18F]Galacto-RGD- or [18F]FDG-uptake. A moderate but significant correlation was found between IAUGC and the SUV’s for [18F]Galacto-RGD (r=0.66, p<0.05). There was no correlation between [18F]FDG and [18F]Galacto-RGD uptake.

rBF and rBV data derived from DCE-MRI do not strongly correlate with [18F]Galacto-RGD- and [18F]FDG-uptake, suggesting that each parameter provides independent information on tumor biology.

DCE-MRI, [18F]Galacto-RGD and [18F]FDG PET provide independent functional and molecular information on tumor biology.

Metz, S, Ganter, C, Rummeny, E, Brix, G, Schwaiger, M, Beer, A, Characterization of Tumor Biology with MRI and PET: Relationship between Microcirculation, Integrin αvβ3 Expression, and Glucose Metabolism  .  Radiological Society of North America 2009 Scientific Assembly and Annual Meeting, November 29 - December 4, 2009 ,Chicago IL. http://archive.rsna.org/2009/8012521.html