Abstract Archives of the RSNA, 2009
VB31-11
Compliance for Mammography, Ultrasound, and Contrast-enhanced MRI during a Multicenter Surveillance of Women at High Risk for Breast Cancer
Scientific Papers
Presented on December 1, 2009
Presented as part of VB31: Breast Series: High-Risk Screening
Francesco Sardanelli MD, Presenter: Consultant, Bracco Group
Franca Podo DSc, Abstract Co-Author: Nothing to Disclose
Flippo Santoro DSc, Abstract Co-Author: Nothing to Disclose
Luca Alessandro Carbonaro MD, Abstract Co-Author: Nothing to Disclose
Giovanni Di Leo, Abstract Co-Author: Nothing to Disclose
Alessandro Del Maschio MD, Abstract Co-Author: Nothing to Disclose
Daniele Vergnaghi MD, Abstract Co-Author: Nothing to Disclose
00030490-DMT et al, Abstract Co-Author: Nothing to Disclose
To evaluate the compliance for mammography, ultrasonography, and MRI of women at genetic-familial high-risk of breast cancer attending a multicenter surveillance program.
IRB approval from each Center and informed written consent were obtained. From June 2000 to January 2007, we enrolled 502 women in 18 Centers: 195 BRCA1 mutation carriers or their first degree relatives; 148 BRCA2 mutation carriers or their first degree relatives; and 159 women enrolled on the only basis of a strong family history of breast or ovarian cancer (three or more events in first or second degree relatives in either maternal or paternal line, including breast cancer in women younger than 60 years and ovarian cancer or male breast cancer at any age). Women with previous personal breast cancer history were included. Two rounds with all three imaging modalities were planned. McNemar test was used.
A total of 502 women were enrolled with an age at entry of 46±12 (46.0+/- 11.8) years (mean ± standard deviation). A total 1,596 screening events were performed. The number of woman who participated in the first round was 502/502 (100%), in the second round 426/502 (84.9%). The number of rounds with all the three modalities was 1368/1596 (85.7%), with mammography and ultrasound 105/1596 (6.6%), with mammography and MRI 39/1596 (2.4%), with mammography alone 27/1596 (1.7%), with MRI alone 20/1596 (1.3%), with ultrasound and MRI 19/1596 (1.2%), with ultrasound alone 18/1596 (1.1%). The compliance for mammography was 1539/1596 (96.4%), higher than that for ultrasound 1510/1596 (94.6%) (P=.012) or for MRI 1446/1596 (90.6%) (P<.001); that for ultrasound was higher than that for MRI (P<.001).
This intensive screening program was accepted by high-risk women with a three-modality compliance of 86%. Mammography remains the mostly performed modality but MRI – notwithstanding the need of intravenous contrast agent injection, prone position, and examination duration not lower than 20 minutes in a closed magnet – was performed in more than 90% of screening events.
The high compliance for MRI makes surveillance programs based on annual MRI feasible in selected high-risk populations.
Sardanelli, F,
Podo, F,
Santoro, F,
Carbonaro, L,
Di Leo, G,
Del Maschio, A,
Vergnaghi, D,
et al, 0,
Compliance for Mammography, Ultrasound, and Contrast-enhanced MRI during a Multicenter Surveillance of Women at High Risk for Breast Cancer. Radiological Society of North America 2009 Scientific Assembly and Annual Meeting, November 29 - December 4, 2009 ,Chicago IL.
http://archive.rsna.org/2009/8007343.html