Masami Goto, Presenter: Nothing to Disclose

Osamu Abe MD, PhD, Abstract Co-Author: Nothing to Disclose

Naoto Hayashi MD, Abstract Co-Author: Research grant, General Electric Company Research grant, TeraRecon, Inc

Shigeki Aoki MD, Abstract Co-Author: Nothing to Disclose

Sachiko Inano, Abstract Co-Author: Nothing to Disclose

Harushi Mori MD, Abstract Co-Author: Nothing to Disclose

Tomohiko Masumoto MD, Abstract Co-Author: Nothing to Disclose

Kenji Ino PhD, Abstract Co-Author: Nothing to Disclose

Keiichi Yano, Abstract Co-Author: Nothing to Disclose

Kyouhito Iida, Abstract Co-Author: Nothing to Disclose

Kazuo Mima PhD, Abstract Co-Author: Nothing to Disclose

Kuni Ohtomo MD, Abstract Co-Author: Nothing to Disclose

et al, Abstract Co-Author: Nothing to Disclose

The aim of the present study is to investigate hippocampal volume change in normal adults divided into eight groups according to their age and gender using high spatial resolution T1-weighted images obtained using 3.0 tesla magnetic resonance (3T-MR) scanners and voxel-based morphometry (VBM).

A total of 412 consecutive healthy subjects participated in this study. MRI data were obtained using 3.0-T scanners (Signa EXCITE HDx, GE Medical Systems, Waukesha, WI, USA) located at the University of Tokyo Hospital, Japan. An 8-channel brain phased-array coil was used as the receiver coil. Three-dimensional fast spoiled-gradient recalled acquisition in the steady state (3D-FSPGR) was used to obtain 180 contiguous sagittal T1-weighted images with a slice thickness of 1.0 mm for VBM analysis.We used Statistical Parametric Mapping 5 (SPM5) software. The 3D-FSPGR images in native space were bias-corrected, spatially normalized, and segmented into gray matter, white matter, and cerebrospinal fluid images.The normalized data smoothed with 6-mm isotropic Gaussian kernels were analyzed with SPM5 employing the framework of the general linear model. Statistical significance for gray matter volume between the paired sequential age groups (subjects in their forties vs fifties, fifties vs sixties, sixties vs seventies) of both males and females was tested with TIV as the confounding covariate.

Significant decrease was found in bilateral hippocampal volume between the groups of females in their forties vs fifties.

Considering a study that reported the average age at menopause in Japanese females is 48.3 years, the results of the current study suggest that the decreased release of estrogen in menopausal women may be associated with hippocampal volume reduction.

the results of the current study suggest that the decreased release of estrogen in menopausal women may be associated with hippocampal volume reduction.

Goto, M, Abe, O, Hayashi, N, Aoki, S, Inano, S, Mori, H, Masumoto, T, Ino, K, Yano, K, Iida, K, Mima, K, Ohtomo, K, et al, , Accelerated Hippocampal Volume Reduction in Females in Their Fifties Using  3T-MR Scanners and VBM.  Radiological Society of North America 2008 Scientific Assembly and Annual Meeting, February 18 - February 20, 2008 ,Chicago IL. http://archive.rsna.org/2008/6015778.html