Akihiko Wada MD, Abstract Co-Author: Nothing to Disclose

Takafumi Hayashi MD, Presenter: Nothing to Disclose

Kazutoshi Kamiyama, Abstract Co-Author: Nothing to Disclose

Ai Kobayashi, Abstract Co-Author: Nothing to Disclose

Youji Tsuchie, Abstract Co-Author: Nothing to Disclose

Takeshi Yoshizako MD, Abstract Co-Author: Nothing to Disclose

Hajime Kitagaki MD, Abstract Co-Author: Nothing to Disclose

et al, Abstract Co-Author: Nothing to Disclose

It is reported that frequency of cognitive dysfunction in diabetes mellitus patients is higher than in non-diabetics. Some epidemiologic study reported the incidence of Alzheimer's disease of aged diabetics population was about 2 times in non-diabetics. For early diagnosis of Alzheimer's disease, utility of hippocampal regional Volume-Based Morphometry (VBM) is proposed. In this examination, we compared the severity of brain atrophy between diabetics group and non-diabetics control group by using VBM..

Our subject were 29 diabetic patients (male: female =15:14, age 59-79 years old , mean age 70.7 years old) and sex- and age-matched (+-2 years) 29 non-diabetic healthy volunteers. VBM of whole brain and hippocampal region was performed on 1.5T MR unit; Magnetom Symphony (Siemens) with following parameters; 3D-GRE imaging (MPRAGE), TR/TE/TI:1750/3.93/1100 (msec), FA:15, Matrix:256x256, FOV:22cm, slice thickness:1.5mm, 120slices. Following three investigation were performed; (1) the severity of hippocampus (mean value of Z score at hippocampal region), (2) the ratio of cerebral atrophy (Z score >2 region to the whole brain), (3) the atrophy severity ratio of the hippocampal region to whole brain. The statistical analysis was performed with unpaired t-test and its significance level was assumed with less than 1% (P<0.01) of critical rate.  

There was a significant difference between diabetics and non-diabetics about the severity of hippocampal atrophy and the ratio of significant atrophic area (Z score>2 ratio). Only in diabetic group, positive correlation between the ratio of regional cerebral atrophy and the severity of hippocampal atrophy was recognized (Spearman's two tail correlation, correlation function: rs=0.775, P<0.01).

Acceleration of cerebral atrophy especially at hippocampus is significant in diabetics in comparison with non-diabetics. Our results prove relation of diabetes mellitus and hippocampal atrophy and support high frequency of Alzheimer disease in diabetics.

Acceleration of cerebral atrophy especially at hippocampus in aged diabetics proves the previous epidemiologic result of high frequency of Alzheimer disease in diabetes mellitus.

Wada, A, Hayashi, T, Kamiyama, K, Kobayashi, A, Tsuchie, Y, Yoshizako, T, Kitagaki, H, et al, , Acceleration of Hippocampal Atrophy in Aged Diabetecs: Volume-based Morphometry Study.  Radiological Society of North America 2008 Scientific Assembly and Annual Meeting, February 18 - February 20, 2008 ,Chicago IL. http://archive.rsna.org/2008/6014093.html