Miriam Antoinette Bredella MD, Presenter: Nothing to Disclose

Madhusmita Misra MD, MPH, Abstract Co-Author: Nothing to Disclose

Karen K. Miller MD, Abstract Co-Author: Nothing to Disclose

Ijad Madisch MD, Abstract Co-Author: Nothing to Disclose

Ammar Sarwar MD, Abstract Co-Author: Nothing to Disclose

Arnold Cheung MD, Abstract Co-Author: Nothing to Disclose

Anne Klibanski MD, Abstract Co-Author: Nothing to Disclose

Rajiv Gupta PhD, MD, Abstract Co-Author: Nothing to Disclose

et al, Abstract Co-Author: Nothing to Disclose

To examine trabecular microarchitecture using ultra high resolution flat panel Volume CT (fpVCT), and bone mineral density (BMD) using Dual-energy X-ray-absorptionmetry (DXA) in adolescent girls with anorexia nervosa (AN) and to compare these results with age-matched normal-weight controls.

The study was approved by our IRB and complied with HIPAA guidelines. Informed consent was obtained from each subject and their parents. We studied 20 adolescent girls, 10 with AN and 10 age and sex matched normal-weight controls (mean age 15.9 years). All subjects underwent fpVCT of the non-dominant ultradistal radius to determine parameters of trabecular microarchitecture: apparent trabecular bone volume fraction (BV/TV,%), trabecular number (TbN,mm-3), trabecular thickness (TbTh,mm) and trabecular separation (TbSp,mm). All subjects also underwent DXA of the spine, hip, and whole body to determine BMD and body composition. Linear regression analysis between trabecular structure parameters, BMD and body composition was performed.

Subjects with AN showed statistically significant lower values in BV/TV, TbTh, and higher values in TbSp compared to normal-weight controls (p<0.001). TbN was lower in AN but the difference was not statistically significant. In contrast, there was no significant difference in BMD between AN and controls. There was a positive correlation between trabecular structure parameters and fat mass and % body fat. BMD parameters showed a positive correlation with BV/TV and TbTh in the control group but not in girls with AN.

FpVCT is a technique that is effective in evaluating trabecular structure in adolescents with AN and demonstrates that bone structure is extremely abnormal in girls with AN compared to normal-weight controls despite normal BMD.

Bone structure is abnormal in adolescents with AN compared to normal-weight controls despite normal BMD. FpVCT allows evaluation of trabecular structure in adolescents with AN.  

Bredella, M, Misra, M, Miller, K, Madisch, I, Sarwar, A, Cheung, A, Klibanski, A, Gupta, R, et al, , Trabecular Structure Analysis of the Distal Radius in Adolescents with Anorexia Nervosa Using Ultra High Resolution Flat Panel Volume CT.  Radiological Society of North America 2008 Scientific Assembly and Annual Meeting, February 18 - February 20, 2008 ,Chicago IL. http://archive.rsna.org/2008/6006933.html