Jose R. Garcia MD, Presenter: Nothing to Disclose

Marina Soler MD, Abstract Co-Author: Nothing to Disclose

M. Aranzazu Santana MD, Abstract Co-Author: Nothing to Disclose

Antonia Blanch, Abstract Co-Author: Nothing to Disclose

Ignasi Carrio MD, PhD, Abstract Co-Author: Nothing to Disclose

Francisco Lomeņa MD, Abstract Co-Author: Nothing to Disclose

To compare patterns of uptake 11C-Choline and 18F-FDG in the early assessment of prostate cancer recurrence.

38 prostate cancer patients with increasing prostate-specific antigen (PSA) range 0,8-8,5 ng/ml, after radical surgery (n:20) or radiotherapy (n:18), underwent whole-body PET-CT using Gemini (Philips) equipped with a GSO crystal and a 16-channel spiral CT. All patients underwent 11C-Choline and 18F-FDG PET-CT in the same day as follows: Choline-PET was performed 5 min. post-injection of the tracer. Immediately after, FDG was injected, and PET scan was performed 1hour later. A site-by-syte analysis of focal increased uptake was evaluated between both tracers by two Nuclear Medicine physicians. Lymph node metastases were confirmed by CT. Bone metastases were confirmed by CT or bone scan. Salvage radiotherapy was done in 17 patients.

With regard to local recurrence 13 patients (30%) showed focal 11C-Choline but only 6 patients (14%) presented with 18F-FDG uptake. 11C-Choline showed focal abnormal pelvic lymph node activity in 7 patients (16%) while 18F-FDG uptake was present in 4 (9%). Mediastinal involvement was observed by 11C-Choline in 6 patients (14%) and in 5 patients (11%) with 18F-FDG. Bone metastases were observed in 3 patients (7%) with both tracers. In one patient 18F-FDG PET showed diffuse uptake in left iliac without 11C-Choline expression related to Paget disease in CT.

Comparative assessment of both tracers indicates that 11C-Choline has a significant potential for early detection and exact localization of recurrent prostate cancer, clearly superior to 18F-FDG in local recurrence and lymph node involvement, while both tracers show similar results in bone metastases.

11C-Choline has a significant potential for early detection and exact localization of recurrent prostate cancer, clearly superior to 18F-FDG in local recurrence and lymph node involvement, while both tracers show similar results in bone metastases.

Garcia, J, Soler, M, Santana, M, Blanch, A, Carrio, I, Lomeņa, F, Intraindividual Comparison of 11C-Choline and 18F-Fluorodeoxyglucose PET-CT in the Early Evaluation of Prostate Cancer Recurrence.  Radiological Society of North America 2007 Scientific Assembly and Annual Meeting, November 25 - November 30, 2007 ,Chicago IL. http://archive.rsna.org/2007/5010971.html