Yoshiharu Ohno MD, PhD, Presenter: Nothing to Disclose

Kenya Murase PhD, Abstract Co-Author: Nothing to Disclose

Hisanobu Koyama MD, Abstract Co-Author: Nothing to Disclose

Munenobu Nogami MD, PhD, Abstract Co-Author: Nothing to Disclose

Daisuke Takenaka MD, Abstract Co-Author: Nothing to Disclose

Yumiko Onishi MD, Abstract Co-Author: Nothing to Disclose

Sumiaki Matsumoto MD, PhD, Abstract Co-Author: Nothing to Disclose

Kazuro Sugimura MD, Abstract Co-Author: Nothing to Disclose

et al, Abstract Co-Author: Nothing to Disclose

et al, Abstract Co-Author: Nothing to Disclose

To evaluate the capability of quantitatively assessed 3D dynamic perfusion MRI for disease severity evaluation in patients with connective tissue disease (CTD).

13 CTD patients underwent 3D dynamic perfusion MRI, echocardiography, pulmonary function test and/ or right heart catheterization. Disease severity in each CTD patient was assessed with regard to diffusing capacity of the lung (DLco) and mean pulmonary arterial pressure (mPAP). All CTD patients were classified into two groups: CTD patient with (n=7) and without (n=6) pulmonary arterial hypertension (PAH). From the signal intensity-time course curve in each subject, quantitatively assessed pulmonary blood flow (PBF), pulmonary blood volume (PBV) and mean transit time (MTT) maps were generated by using central volume principle, indicator dilution theory, and deconvolution analysis on a pixel-by-pixel basis. On quantitative perfusion parameter maps, regional perfusion parameters were measured in 6 ROIs in both lungs on each slice. Then, PBF, PBV and MTT in each subject were determined as average of all ROI measurements. To compare each perfusion parameter between CTD patient with and without PAH groups, PBF, PBV and MTT were statistically compared by Student’s t-test. To determine the capability of disease severity evaluation in CTD patients, PBF, PBV and MTT were statistically correlated with DLco and mPAP.

On comparison of each pulmonary perfusion parameter between CTD patient with and without PAH groups, PBF of CTD patient without PAH group was significantly higher than that of CTD patient with PAH group (p=0.047). On correlation among each pulmonary perfusion parameter, PBF had significant and moderate correlation with DLco (r=0.56, p=0.045) and mPAP (r=0.64, p=0.018).

Quantitatively assessed 3D dynamic perfusion MRI has a potential for disease severity evaluation in patients with connective tissue disease.

Quantitatively assessed 3D dynamic perfusion MRI can evaluate disease severity as indicated by DLco and mPAP in patients with connective tissue disease

Ohno, Y, Murase, K, Koyama, H, Nogami, M, Takenaka, D, Onishi, Y, Matsumoto, S, Sugimura, K, et al, , et al, , Quantitatively Assessed 3D Dynamic Perfusion MRI of the Lung: Capability for Disease Severity Evaluation in Patients with Connective Tissue Disease.  Radiological Society of North America 2007 Scientific Assembly and Annual Meeting, November 25 - November 30, 2007 ,Chicago IL. http://archive.rsna.org/2007/5003468.html