Ettore Squillaci MD, Presenter: Nothing to Disclose

Mauro Di Roma MD, Abstract Co-Author: Nothing to Disclose

Guglielmo Manenti MD, Abstract Co-Author: Nothing to Disclose

Roberta Mastrangeli, Abstract Co-Author: Nothing to Disclose

Stefano Mancino MD, Abstract Co-Author: Nothing to Disclose

Giovanni Simonetti MD, Abstract Co-Author: Nothing to Disclose

To correlate ADC value of diffusion-weighted MR imaging (DWI) at 3 Tesla (3T) with tumour cellularity in malignant renal tumours.

10 normal volunteers and 28 Patients with histologically proven malignant renal lesion (18 clear cell Ca, 4 papillary variant Ca, 3 granular cell Ca, 1 sarcomatoid Ca, 2 transitional cell Ca) underwent MRI of the kidneys by using a 3 T superconductive magnet (Philips Achieva, Best, The Netherlands). Axial T1 an T2 weighted images, with and without fat-suppression, and Coronal T2 weighted images were acquired in each patient. DWI were obtained on axial planes during breath-hold (19 seconds) with a SE-EPI single shot sequence (TR 2275 ms; TE 58 ms; FA 90°; EPI Factor 53; Thickness 5 mm) with max b factor of 500 s/mm2. Axial dynamic contrast-enhanced 3D T1 FFE fat-sat sequence was performed in all patients. All lesions were surgically resected and the mean tumor cellularity was calculated as the number of tumour cell nuclei in 10 high-magnification fields in area without regressive phenomena. Comparison between tumour cellularity and the mean ADC value were performed using simple linear regression analysis.

Mean ADC value in normal renal parenchyma was 2.35 ± 0.31 x 102 mm3/sec, while mean ADC value in malignant renal tumours was x 102 mm3/sec. In our series there was no statistically significative difference between ADC values of different histotype (1.73 ± 0.8 clear cell Ca, 1.84 ± 0.4 papillary variant Ca, 1.67 ± 0.9 granular cell Ca, 1.71 ± 0.3 sarcomatoid variant Ca, 1.43 ± 0.6 transitional cell Ca). The analisys of mean ADC values showed an inverse linear correlation with cellularity in malignant renal tumours with a Pearson’s correlation coefficient r = -0.71 (p<0.01).

DWI with a 3T MR system seem to be a feasible and reliable technique to evaluate renal parenchyma and to differentiate malignant renal tumours on the basis of tumour cellularity.

To describe the potential of DWI at 3T in malignant renal tumours and to asses the correlation between ADC and hystology of the different renal lesions.

Squillaci, E, Di Roma, M, Manenti, G, Mastrangeli, R, Mancino, S, Simonetti, G, Correlation between ADC Value of Diffusion-weighted Imaging at 3 T MR and Cellularity in Malignant Renal Tumours.  Radiological Society of North America 2006 Scientific Assembly and Annual Meeting, November 26 - December 1, 2006 ,Chicago IL. http://archive.rsna.org/2006/4431400.html