Yaqing Chen PhD, Presenter: Nothing to Disclose

Kemin Chen MD, PhD, Abstract Co-Author: Nothing to Disclose

Lianping Lu PhD, Abstract Co-Author: Nothing to Disclose

Yongchang Zhou, Abstract Co-Author: Nothing to Disclose

Ren Wang, Abstract Co-Author: Nothing to Disclose

Huizheng Zhang MD, Abstract Co-Author: Nothing to Disclose

To evaluate prostate cancer detection with a MRS targeted biopsy approach compare with sextent biopsy.

40 patients with an elevated PSA (above 4.0ng/ml) or abnormal digital rectal examination were underwent MRS before biopsy (siements 1.5T symphony). 32 patients underwent first biopsy whereas 8 had repeat biopsy. Under transrectal ultrasound guide, transperineal sextent biopsy were performed and up to three additional targeted biopsy cores were obtained from the sites of abnormal MRS. One biopsy core was taken if the site of abnormal MRS and sextent biopsy was same, and the coer was added the date of both targeted and sextent boipsy.

Cancer was proven in 41 cores of 15 cases from 324 biopsy cores of 40 cases, 14.2% (34/240) of sextent biopsy and 19.7% (29/147) of targeted biopsy (p<0.01) .Cancer was discovered in 10 patients by both techniques, in 3 by sextent biopsy and 2 by targeted alone. The core of the cancer was obtained in 22 cores by both techniques, in 7 cores by targeted alone included 3 in central zone, 2 in transitional zone and 2 in the base and 12 cores by sextent biopsy alone included 4 in the mid-gland and 8 in the apex. Cancer was discovered in 4 from 8 patients of repeat biopsy, including 3 by targeted biopsy and 1 by sextent biopsy alone. The 3 patients with cancer by targeted biopsy alone included 2 positive cores in the transitional zone, 1 in the central zone and 1 in the base.

The detection of the prostate cancer rate of targeted biopsy is significantly higher than sextent biopsy approach and is useful to discover cancer cores located in central and transitional zone. However targeted biopsy with basis of MRS failed to detected 3 prostate cancer and low proportion in apex and mid-gland. Targeted biopsy with basis of MRS just be as a supplement modality to detect cancer cores especially when the previously sextent biopsy was negative.

Chen, Y, Chen, K, Lu, L, Zhou, Y, Wang, R, Zhang, H, Prostate Cancer Detection with Targeted Biopsy Basis of MRS.  Radiological Society of North America 2005 Scientific Assembly and Annual Meeting, November 27 - December 2, 2005 ,Chicago IL. http://archive.rsna.org/2005/4416982.html