Hiroshi Anai, Presenter: Nothing to Disclose

Barry Tadao Uchida BS, Abstract Co-Author: Nothing to Disclose

Josef Rosch MD, Abstract Co-Author: Nothing to Disclose

Frederick Saul Keller MD, Abstract Co-Author: Nothing to Disclose

Hiroshi Sakaguchi MD, Abstract Co-Author: Nothing to Disclose

Kimihiko Kichikawa MD, Abstract Co-Author: Nothing to Disclose

The purpose of this study was to investigate how much the restriction of blood flow and/or ventilation affects the coagulation size of radiofrequency (RF) ablation of lung parenchyma.

Thirty-one RF ablations were created in vivo in 16 normal lungs of 8 swine with 2cm-LeVeen needles. Eight RF ablations were performed as control (C), 8 with balloon occlusion of the bronchus (BO), 8 with occlusion of pulmonary artery (PO) and 7 with occlusion of both the bronchus and pulmonary artery (BPO). Coagulation diameters and volumes of each ablation zone were compared on CT and gross specimen examinations.

Twenty-six coagulation zones were suitable for evaluation, 8 in C, 5 in BO, 7 in PO and 6 in BPO groups. Mean coagulation diameter was 21.5 ±3.5 mm on CT and 19.5 ±1.78 mm on gross specimen examination in C group, 26.5±5.1 mm and 23.0±2.7 mm respectively with BO, 29.4±2.2 mm and 27.4±2.9 mm respectively with PO, and 32.6±3.33 mm and 28.8±2.6 mm respectively with BPO. Mean coagulation volumes were 3.39 3±1.52 cm³ on CT and 3.01±0.94 cm³ on gross examinations in C group, 5.22±0.85 cm³ and 6.56±2.47 cm³ respectively with BO, 9.97±2.91 cm³ and 10.93±2.17 cm³ respectively with PO, and 11.06±3.27 cm³ and 13.81±3.03 cm³ with BPO. Mean coagulation diameters on gross examination and coagulation volumes on CT and gross examination with PO or BPO were significantly larger than that in C group (p<0.0001, p<0.0001, p<0.0001) or with BO (p<0.05, p<0.005, p<0.005).

Restriction of ventilation and particularly of pulmonary artery blood flow are effective factors in increasing the coagulation size of RF ablation of the lung parenchyma. Exploration of RF ablation in experimentally induced lung tumors, preferably in large animals will be necessary to determine the value of these restrictions for potential clinical use.

Anai, H, Uchida, B, Rosch, J, Keller, F, Sakaguchi, H, Kichikawa, K, Effect of Blood Flow and/or Ventilation Restriction on Radiofrequency Coagulation Size in the Lung: An Experimental Study in Swine.  Radiological Society of North America 2005 Scientific Assembly and Annual Meeting, November 27 - December 2, 2005 ,Chicago IL. http://archive.rsna.org/2005/4416608.html