Yuting Liang, Presenter: Nothing to Disclose

Ma Daqing, Abstract Co-Author: Nothing to Disclose

Wen He, Abstract Co-Author: Nothing to Disclose

Erhu Jin, Abstract Co-Author: Nothing to Disclose

To use contrast-enhanced CT imaging and a distributed-parameter tracer kinetics model for prospectively evaluating the vascular characteristics of prostate cancer and to correlate these with tumor stage, histological grade and PSA.

MRI and contrast-enhanced CT imaging were acquired in 93 patients, including 38 cases with histologically proved adenocarcinoma of the prostate, 42 cases with BPH, and 13 cases with normal prostate. The slice positions of CT images(GE 8slices CT) were same to that of MR sections on which prostate cancer or BPH were visualized clearly. With the aid of the biopsy (transrectal ultrasound guided systematic 12 biopsy) and T2WI, ROIs of tumor, BPH, normal peripheral zone and central gland were drawn at the corresponding regions on the CT images. These regions were outlined to encompass as much tumor, BPH and normal prostate as was visible in the selected section. Perfusion parameters including blood flow(BF), blood volume(BV), mean transmit time(MTT) and capillary vessel permeability surface(PS)from all the ROIs showed on functional images were analyzed.

From functional maps, locations of increased BF and BV regions were consistent with the tumor regions showed on MRI in 63.1% patients. Regions of increased BF and BV were larger or more than tumor regions on MRI in 15.8% cases. Regions of increased BF and BV located in central gland in 13.2% patients.Mean BF and BV were significantly higher in 38 prostate tumors (62.29ml/min/100ml, 12.03ml/100ml) than in 13 normal prostates(11.64,2.93, p<0.001) and in 42 BPH (19.24, 4.14 , p<0.001). Mean PS was significantly higher in prostate tumors(26.41ml/min/100ml) than in normal prostates (13.18ml/min/100ml,p<0.001), but no differences compared with those in BPH (22.49ml/min/100ml).There were correlations between tumor stage, histological grade with BF and BV（BF r=0.514,p=0.001; r=0.659, p<0.001; BV r=0.464,p=0.004; r=0.360,p=0.037. Correlation between PSA and BF(r=0.463, p<0.001）was also noted.

Functional CT imaging has the potential to provide important information about vascular characteristics in prostate cancer and may be helpful for guiding biopsy and assessing individual prognosis.

Liang, Y, Daqing, M, He, W, Jin, E, Functional CT Imaging of Prostate Cancer: Correlation with MRI and Histological Result.  Radiological Society of North America 2005 Scientific Assembly and Annual Meeting, November 27 - December 2, 2005 ,Chicago IL. http://archive.rsna.org/2005/4416503.html