Richard H. Moore AB, Presenter: Nothing to Disclose

Alexander Stewart MS, Abstract Co-Author: Nothing to Disclose

Tao Wu PhD, Abstract Co-Author: Nothing to Disclose

Daniel Benjamin Kopans MD, Abstract Co-Author: Nothing to Disclose

Elizabeth Ann Rafferty MD, Abstract Co-Author: Nothing to Disclose

Dianne Georgian-Smith MD, Abstract Co-Author: Nothing to Disclose

Demonstrate the practical workflow and first results from second-generation DBT in the 3000-subject NIH-NIBIB trial. The presentation characteristics and measured parameters of screening DBT interpretation will be provided.

Conventional two-view mammography (CTVM) screening workflow has become highly organized to reduce reading delay. Radiologists expect to view CTVM in batches on film alternators that change cases in a second. A similar case-to-case advance rate (CCAR) will require 1500 MB of new image data must be loaded just as quickly. MGH has designed and implemented multiple 2-gigavoxel review workstations (2GRW) which meet this requirement using industry-standard RAID-1 striping 4 SCSI disks under dual-Xeon Intel-server architecture. Cases are organized using a similar RAID-5 backed DBT worklist and archive management system. 2- and 4-screen 2GRW configurations using 9-megapixel IBM color monitors. Case load times, and CCARs were demonstrated with the 470 case DBT dataset collected under USArmy CTR DAMD17-98-8309. A training set of ten DBT cases and prior mammograms were reviewed by each radiologist prior to participation. Subsequently, groups of 30 DBT cases were presented for review. These were first interpreted without prior studies and then again with prior mammograms. Times were automatically recorded for CCAR, request-to-delivery (RTD), radiologist-switch (RS), and radiologist active review(RAR) to score relevant times to perform DBT interpretation .

CCARs in the range of 0.5 to 1 second have been easily achieved measured with cases predesignated on worklist employing data acquired via 1st generation DBT on 470 volunteers. We will report statistics for CCAR, RTD, RS and RAR results on our screening study to date. Preliminary FP,FN and PPV rates compared to CTVM, both Denovo and with priors will summarize 2GRW performance for DBT in the screening setting. About 700 cases will be available for summary and highlight by RSNA-2005

For DBT to replace conventional 2-dimensional mammography, the efficient display and interpretation of huge datasets is critical. We have developed, used and characterized viable screening DBT solution.

D.B.K.: Daniel Kopans is a patent holder of breast tomosynthesis and receives some support from GEMSR.H.M.: Receives some support from GEMST.W.: Supported by Susan G. Komen Breast Cancer Foundation Grant PDF0402784R.H.M.,A.S.,T.W.,D.B.K.,E.A.R.,D.G.: Supported in part by NIBIB R33 CA 107863A.S.: Under contract to develop 2GRW for MGH Breast Imaging

Moore, R, Stewart, A, Wu, T, Kopans, D, Rafferty, E, Georgian-Smith, D, Second-generation Digital Breast Tomosynthesis (DBT) in the Screening Setting: Workflow and Preliminary Results.  Radiological Society of North America 2005 Scientific Assembly and Annual Meeting, November 27 - December 2, 2005 ,Chicago IL. http://archive.rsna.org/2005/4411096.html