Veronika Gazhonova MD, PhD, Presenter: Nothing to Disclose

Alexander Zubarev MD, PhD, Abstract Co-Author: Nothing to Disclose

Yevsey Mazo MD, PhD, Abstract Co-Author: Nothing to Disclose

Larisa Ivanchenko MD, Abstract Co-Author: Nothing to Disclose

To investigate 3D US Doppler characteristics of acute stage of Peyronie’s disease and to evaluate possibilities of US in comparance to CE-MRI in the diagnosis of acute Peyronie’s disease.

26 pts with clinical presentation of Peyronie’s disease underwent US study after intracavernous injection of prostaglandin E1. Inclusion criteria were penile curvature, palpable plaque, penalgia during intercourse. US examination starts in latent or tumescent phases of erection. 3D MPR of the penis with axial, sagittal and coronal images were produced for better evaluation of the thickening of tunica albuginea (TA) and surrounding plaques tissue. Power Doppler vascularity in the thickened regions of TA were studied with Spectral Doppler analysis. Resistive indices in the small vessels detected with Power Doppler were measured. US results were compared with CE-MRI data.

21 pts had Peyronie’s disease (13 active stage, 8 chronic stage), in 5 the diagnosis was rejected (1 left cavernosal artery hypoplasia, 2 septal defects: 1- arterial, 1 –venous fistulas due to penile fracture, 2 partial cavernosal fibrosis). Increased inflammatory vascularity was revealed in thickened areas of TA or plaque’s surrounding tissue in all cases of acute stage disease. The values of RI in the increased vascularity areas were 0,53+/-0,03 (range 0,5-0,59). No flow surrounding plaques was detected in chronic stage of the disease. 3D Doppler US sensitivity in detection, location and extension of the acute stage plaques in pts with Peyronie’s disease were 92%, specificity 100% in comparance to CE-MRI. CE-MRI failed to detect the cause of penile curvature in 3 cases of vascular disorders.

3D US Doppler can be a method of choice in detection of acute stage Peyronie’s disease. 3D Doppler US is superior to CE-MRI in evaluation of pts with septal defects and cavernosal artery hypoplasia.

Gazhonova, V, Zubarev, A, Mazo, Y, Ivanchenko, L, Three-dimensional and Power Doppler Sonography in Detection of Acute Stage of Peyronie’s Disease.  Radiological Society of North America 2005 Scientific Assembly and Annual Meeting, November 27 - December 2, 2005 ,Chicago IL. http://archive.rsna.org/2005/4410540.html