Kyung Soo Lee MD, Abstract Co-Author: Nothing to Disclose

Yeon Joo Jeong MD, Presenter: Nothing to Disclose

Man Pyo Chung, Abstract Co-Author: Nothing to Disclose

Myung Jin Chung MD, Abstract Co-Author: Nothing to Disclose

Joungho Han, Abstract Co-Author: Nothing to Disclose

O Jung Kwon , Abstract Co-Author: Nothing to Disclose

To demonstrate initial and serial HRCT findings of pathologically proven UIP and NSIP and correlate the changes with functional changes.

Serial HRCT scans and pulmonary function test (PFT) results were retrospectively analyzed in 104 patients with pathologically proven UIP (n=76) and NSIP (n=28). Two independent observers assessed the presence and extent of various patterns of parenchymal abnormalities at HRCT. Interval change in extent was considered present if there was a greater than 10% change between initial and follow-up CT. Correlation between changes in the extent of each parenchymal and total abnormality and those in the extent of PFT was performed by using Pearson or Spearman’ rho analysis.

On initial CT, the mean extent of overall lung abnormality, ground-glass opacity (GGO), irregular linear opacities, honeycombing, consolidation, and nodular opacities were 36%, 21%, 8%, 4%, 3%, 0% in NSIP; 38%, 20%, 9%, 6%, 2%, 1% in UIP, respectively (significantly different in irregular linear opacity and honeycombing; p values, 0.016 and 0.012, respectively). There was an improvement in overall extent in 10 (43%) and 10 (18%) patients (significantly better in NSIP, p = 0.016 at Mann-Whitney U test), deterioration in 5 (22%) and 9 (16%) patients (no difference, p = 0.363) of NSIP and UIP, respectively. In the remaining 8 (35%) and 38 (66%) patients of NSIP and UIP, the interval change was less than 10%. The change in the overall extent (r = -.585, p = < 0.001 with FVC; r = -.315, p = 0.007 with DLCO), GGO (r = -.603, p = < 0.001 with FVC; r = -.364, p = 0.002 with DLCO), and irregular linear opacity (r = -.415, p = < 0.001 with FVC; r = -.256, p = 0.034 with DLCO) of parenchymal abnormalities at HRCT showed good correlation with changes in forced vital capacity (FVC) and diffusion capacity of CO gas (DLCO).

The initial HRCT findings of UIP and NSIP are overlapping, although irregular linear opacity and honeycombing are significantly larger in extent in UIP. Patients with NSIP have more chance to show improvement with treatment. Changes in overall extent, GGO and irregular linear opacity at CT show positive correlation with changes in pulmonary function.

Lee, K, Jeong, Y, Chung, M, Chung, M, Han, J, Kwon , O, Usual Interstitial Pneumonia versus Non-specific Interstitial Pneumonia: Serial High-Resolution CT Findings Correlated with Pulmonary Function.  Radiological Society of North America 2004 Scientific Assembly and Annual Meeting, November 28 - December 3, 2004 ,Chicago IL. http://archive.rsna.org/2004/4410801.html