Wang Xifu MD, Abstract Co-Author: Nothing to Disclose

Bai Renju MD, Abstract Co-Author: Nothing to Disclose

Wang Song, Abstract Co-Author: Nothing to Disclose

Sun Haoran, Abstract Co-Author: Nothing to Disclose

Bai Xu, Abstract Co-Author: Nothing to Disclose

Yiming Li MD, Presenter: Nothing to Disclose

Li Yajun, Abstract Co-Author: Nothing to Disclose

To analyze the correlation between the typical findings of dynamic contrast-enhanced CT (DCT) and tumoral angiogenesis[microvessel density, MVD and vascular endothelial growth factor,VEGF)] of adenomas and nonadenomas so that enhancement mechanism of DCT of them was correctly explained.

Forty-two cases with 46 adrenal masses proven surgically and pathologically were included in the study, which was composed of 23 adenomas, 18 nonadenomas and 5 hyperplastic nodules. DCT and angiogenesis were studied in all adrenal masses. Appearances of DCT of adenomas and nonadenomas were first evaluated, and then, to further explore whether enhanced characteristics of DCT of them were closely correlated with tumoral angiogenesis.

Adrenal adenomas were significantly different from nonadenomas in T-D curve, 7min-delayed Washr and Washa of DCT. The mean MVD and VEGF expression had significant difference between Group faster Washout(type A,C) and Group slower Washout(type B,D,E), 7min-delayed Washr=34% and Washa=43%(P=0.000),which showed their close correlation of both enhancement appearances of DCT and MVD and VEGF expression of adrenal masses. On the other hand, there was significant difference in MVD and VEGF expression between adenomas and nonadenomas.

MVD and VEGF would be the main pathological factors of DCT of adrenal masses, which resulted in different T-D curve, Washr and Washa of adrenal DCT.

Xifu, W, Renju, B, Song, W, Haoran, S, Xu, , Li, Y, Yajun, L, Adrenal Adenomas and Nonadenomas: The Preliminary Study of Correlation between Appearances of DCT and Tumora Angiogenesis.  Radiological Society of North America 2004 Scientific Assembly and Annual Meeting, November 28 - December 3, 2004 ,Chicago IL. http://archive.rsna.org/2004/4402973.html