Cheng-Hui Chiu, Presenter: Nothing to Disclose

Pau-Yang Chang, Abstract Co-Author: Nothing to Disclose

Andy S Chou, Abstract Co-Author: Nothing to Disclose

Pao-Sheng Yen, Abstract Co-Author: Nothing to Disclose

Sea-Kiat Lee, Abstract Co-Author: Nothing to Disclose

Chau-Chin Lee, Abstract Co-Author: Nothing to Disclose

Leukoaraiosis(LA), thought as a risk factor of stroke, is a neuroimaging finding caused by several pathological changes (demyelination, gliosis, cavitated and non cavitated small deep infarction) and etiologies (hypoperfusion, vessel lipohyalinosis); It is thought that arterial hypertension is a factor associated with LA. However, some patients with normal blood pressure, or even hypotension, also have LA change. This study collects sixteen hypotension cases with LA and try to assay factors other than hypertension relate to LA

From 2000 September to 2003 November, 29 cases with hypotension (systolic blood pressure less than 90 mmHg and diastolic blood pressure less than 60 mmHg), and MRI shows leukoaraiosis change on MRI are included in this study. Retrospective review their age, gender, and laboratory data as well as creatine, uric acid, LDH, HDL-C, LDL, triglyceride(TG), total cholesterol( TCH), fasting glucose(Glu-AC), platelet, ESR, to assay the tendency between these laboratory data and presence of leukoaraiosis.

In these 29 cases, three (10.3%) are men and 26 are women (89.7%). Age ranged from 22 to 67 year-old with mean 50 y/o and standard deviation 11 y/o. Eleven patients (38%) are younger than 45 y/o. Fourteen of 14 (100%) patients have normal creatinine and uric acid levels (14/14). Six of 14 patients (43%) have elevated TG (>130 mg/dL). Five of 10 (50%) patients have elevated TCH. One of 12 patients (8.3%) have hyperglycemia. Six of 9 (67%) patients have elevated ESR (>10 mm/hour)..

Arterial hypertension was expected to be the main factor associated with LA. In contrast, this study presents hypotensive patients with LA and found that predominet in female, common in young (<60 y/o), associated with hyperlipidemia and elevated ESR.

Chiu, C, Chang, P, Chou, A, Yen, P, Lee, S, Lee, C, Leukoaraiosis in Hypotensive Patients to Assay Factors Other than Hypertension.  Radiological Society of North America 2004 Scientific Assembly and Annual Meeting, November 28 - December 3, 2004 ,Chicago IL. http://archive.rsna.org/2004/4402371.html