Abstract:
Abstract #800059
Russ
savage
2
11
2003-11-14T16:03:00Z
2003-11-14T16:03:00Z
1
309
1765
United Stationers Supply Co.,
14
3
2167
9.3821
2.85 pt
2
Purpose: CT contrast reactions are currently one of the main
concerns of quality of care in Radiology. The objective of the present study
was to determine the incidence of adverse reactions caused by universal use of
a non-ionic CT contrast agent and to assess the associated risk factors.
Methods and Materials: A two years (6/2001 – 5/2003)
prospective study was conducted in a large urban teaching hospital and included
all consecutive patients (n=29,508) that underwent contrast-enhance CT after
intravenous injection of Iopromide at an iodine concentration of either 300
mgI/ml or 370 mgI/ml. Variables assessed included (i) patients gender and age,
(ii) medical history pertaining to allergies and risk factors, (iii) patient
admission status (out-patient, in-patient, ED), (iv) dose of contrast agent,
(v) clinical type of reaction, (vi) severity of reaction and (vi) treatment
provided. Descriptive analyses of the variables, comparisons of means and
proportions using T-Student and Chi-Square tests were conducted.
Results: The incidence of contrast reactions was 0.7%
(211/29,508): 75.3% (159) in females and 24.7% (52) in males. The average age
was 50.5 year (SD 15y). Dermal reactions (n=161) were the most frequent (77%).
The reactions were classified as mild in 89% (n=188), moderate in 9% (n=19) and
severe in 2% (n=4). 42% (89/211) of the patient required medical treatment.
History of allergy was present in 43.6% (92/211) of patients while 13.7%
(29/211) had documented prior contrast reactions. There were no statistically
significant differences in the number of reactions depending on the dose of
contrast agent administered (p=.350) and age of the patients (p=.089). The
analysis showed that females (p<.001) and outpatients (p<.001) had statistically
significant greater incidence of reactions.
Conclusions: The incidence of CT contrast reactions with
universal use of non-ionic contrast was less than 1%, within the current
quality standard range (0.4%-3.1%). Females and outpatients had a significant
higher incidence of contrast reactions. Importantly, contrast dose and patients
age did not affect the incidence.
Oliva MD, M,
Hot Topic: Universal Use of Non-ionic CT Contrast Material: Assessment of Incidence and Main Risk Factors. Radiological Society of North America 2003 Scientific Assembly and Annual Meeting, November 30 - December 5, 2003 ,Chicago IL.
http://archive.rsna.org/2003/3800059.html
