Abstract:
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Purpose: The purpose of the this study was analysis of high-resolution CT(HRCT) finding of asthmatics and control subjects, and to evaluate the relationship between HRCT findings and pulmonary function test in asthmatic subjects. And try to evaluate the correlation between the bronchial wall thickening with pathologic findings and reflect the thickenining of epithelial basement membrane on basis of the HRCT findings.
Methods and Materials: Using the HRCT, the author analyzed the ratio of bronchial wall thickness, the frequency of bronchial dilatation, the extent of air trapping and centrilobular nodules. In addition, the author assessed HRCT findings of 52 asthmatic patients for correlation with pulmonary function test and then obtained bronchoscopic biopsy at the second divisional branch of 12 patient among the 52 asthmatics. The author measured the thickness of epithelial layer and basement membrane after Hemotoxylin-Eosin stain and then statistically compared with bronchial wall thickening on HRCT.
Results: Among the total 52 asthmatics, the bronchial wall thickening on HRCT showed significant correlation with FEV1 (p=0.006) and TLC (p=0.012). And PEFR (p=0.04) shows significant correlation with the air trapping on HRCT statistically. Among the 12 patient of 52 asthmatics, bronchial wall thickening on HRCT shows statistically significant correlation with basement membrane thickness on pathology, but not with epithelial layer thickeness on pathology (p=0.023, r=0.642).
Conclusion: In conclusion, the ratio of bronchial wall thickening between asthmatics and control subjects are significantly different on HRCT. The grade of bronchial wall thickening shows significant different FEV1 and TLC statistically, and that of extent of air trapping reveal significant different PEFR statistically. The bronchial wall thickening on HRCT reflect the thickness of epithelial basement membrane.
Paik MD, S,
Correlation of Bronchial Wall Thickness between HRCT and Microscopic Finding in Asthmatic Patients. Radiological Society of North America 2003 Scientific Assembly and Annual Meeting, November 30 - December 5, 2003 ,Chicago IL.
http://archive.rsna.org/2003/3108593.html