Abstract Archives of the RSNA, 2003
M10-1126
Extracorporeal High Intensity Focused Ultrasound Ablation in the Treatment of 1038 Patients with Solid Carcinomas
Scientific Papers
Presented on December 3, 2003
Presented as part of M10: Vascular Interventional (Tumor Ablation)
Feng Wu MD, PhD, PRESENTER: Nothing to Disclose
Abstract:
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Purpose: To introduce our clinical experience of using extracorporeal
high-intensity focused ultrasound (HIFU) for the treatment of patients with
various kinds of solid tumors.
Methods and Materials: From December 1997 to October 2001, a total of 1038 patients
with solid tumors underwent HIFU ablation in ten Chinese hospitals. The tumors
included primary and metastatic liver cancer, malignant bone tumors, breast
cancer, soft tissue sarcomas, kidney cancer, pancreatic cancer, abdominal and
pelvic malignant tumors, uterine myoma, benign breast tumors, hepatic
hemangioma and other solid tumors. Real-time ultrasound-guided HIFU therapeutic
system (Chongqing Haifu (HIFU) Tech Co., Ltd, China) was used in this study. It
consists of a diagnostic US device, units for computer automatic control,
6-direction movement and therapeutic planning system, an US generator,
integrated US therapy transducers, and a degassed water circulation unit. The
majority of treated lesions were more than 5 cm in diameter. Most of them were
exposed at acoustic focal peak intensities from 5,000 to 15,000 W/cm2 in a
single session with either 0.8 or 1.6 MHz. Our goals of HIFU ablation in
patients with early-stage cancer were curative, and the HIFU targeted-region
consisted of the primary cancer and a normal tissue margin about 1.5-2.0 cm
around the cancer. But in patients with advanced-stage cancer HIFU was
palliative, to impede tumor growth and to improve the quality of life.
Results: Pathological examination showed that the target region presented clear
evidence of cellular destruction. Small blood vessels less than 2 mm in
diameter were severely damaged. Furthermore, definite changes in malignant
characteristics of treated cancer cell including proliferation, invasion,
metastasis, and immortalisation were observed. Follow-up DSA, CT, MR and color
Doppler US revealed that there was no, or reduced, blood supply in the
treated-tumor, and SPECT showed that no uptake of radioisotope was observed
after HIFU, both indicating a positive therapeutic response and an absence of
viable tumor. Imaging at 6-12 months can showed obvious regression of the
lesion. 4-year follow-up data were collected in patients with HCC,
osteosarcoma, and breast cancer. Among patients treated with HIFU, an extremely
low major complication rate was observed.
Conclusion: Non-invasive HIFU ablation is safe, effective, and feasible for the
treatment of patients with various kinds of solid carcinomas. (F.W. is on the
board of, an employee of, and a shareholder in Chongqing Haifu (HIFU) Tech Co.
Ltd., China. Z.W. is on the board of, a shareholder in and a consultant to Chongqing
Haifu (HIFU) Tech Co. Ltd.)
Questions about this event email: mfengwu@yahoo.com
Wu MD, PhD, F,
Extracorporeal High Intensity Focused Ultrasound Ablation in the Treatment of 1038 Patients with Solid Carcinomas. Radiological Society of North America 2003 Scientific Assembly and Annual Meeting, November 30 - December 5, 2003 ,Chicago IL.
http://archive.rsna.org/2003/3107111.html