RSNA 2003 

Abstract Archives of the RSNA, 2003


500-p

A Prospective Radiologic-Pathologic Study of Minute Lung Opacities (5mm or less in diameter) on Multi-detector Row High-Resolution CT of Whole Lung Lobe

Scientific Posters

Presented on December 3, 2003
Presented as part of L03: Chest Lung Nodules

Participants

Hiroyuki Ishikawa MD, PRESENTER: Nothing to Disclose

Abstract: HTML Purpose: High resolution CT can detect small lung lesions and, therefore, there is a possibility of finding early lung cancer. To evaluate the clinical significance of minute lung opacities (5mm or less in diameter) on multidetector-row high-resolution CT (MD-HRCT), we examined radiologic-pathologic correlation of these opacities here. Methods and Materials: Ten patients who underwent lobectomy for primary lung cancer (8 adenocarcinoma and 2 squamous cell carcinoma) were enrolled into this prospective study. Two thoracic radiologists without knowledge of pathological findings interpreted preoperative MD-HRCT (1.25mm thickness) covering the whole lobe using a MDCT scanner (LightSpeed QX/i, GE, Milwaukee, Wi) and pointed out any focal opacity excluding the main primary tumors. The resected lobes were fixed and sectioned into slices 5mm or less in thickness. Specimens were taken from the macroscopic lesions or from the regions corresponding to these opacities on MD-HRCT. Two surgical pathologists without knowledge of these HRCT findings evaluated all specimens. Results: The MD-HRCT demonstrated 144 opacities. One hundred thirty-nine opacities were 5mm or less in diameter and were classified into 2 groups: 15 nodular opacities and 124 focal ground-glass opacities (FGGO). In 3 of 15 nodular opacities and in 100 of 124 FGGO, there were no significant pathologic changes corresponding to these HRCT findings. On pathologic examination, 12 nodular opacities were diagnosed as 1 papillary neoplastic lesion and 11 non-neoplastic lesions, whereas of 24 FGGO, 7 were atypical adenomatous hyperplasias (AAH), 5 bronchioloalveolar carcinomas (BAC) and 12 non-neoplastic lesions. This study showed the usefulness of MD-HRCT in detecting pre-invasive lesions or very early lung cancers. Conclusion: The detection of minute FGGO on MD-HRCT is important to identify AAH and BAC 5mm or less in diameter.       Questions about this event email: iskw@med.niigata-u.ac.jp

Cite This Abstract

Ishikawa MD, H, A Prospective Radiologic-Pathologic Study of Minute Lung Opacities (5mm or less in diameter) on Multi-detector Row High-Resolution CT of Whole Lung Lobe.  Radiological Society of North America 2003 Scientific Assembly and Annual Meeting, November 30 - December 5, 2003 ,Chicago IL. http://archive.rsna.org/2003/3104278.html