RSNA 2003 

Abstract Archives of the RSNA, 2003


Q15-1328

External Beam Radiotherapy as Treatment for Primary Prostate Cancer in Very Elderly Patients

Scientific Papers

Presented on December 4, 2003
Presented as part of Q15: Radiation Oncology and Radiobiology (Genitourinary Cancer II)

Participants

Melvin Deutsch MD, PRESENTER: Nothing to Disclose

Abstract: HTML Purpose: This is a retrospective review to determine tolerance and outcome of external beam radiotherapy for treatment of primary carcinoma of the prostate in men over age 80 years. Methods and Materials: Thirty-three patients, all at least 80 years old, were treated with external beam radiotherapy for primary carcinoma of the prostate. The pre-radiotherapy PSA varied from 6.6 to 91 (median 15.6). Only six patients had a pre-therapy PSA level below 10. In eleven patients, pathology revealed adenocarcinoma, Gleason grade 8 or above. Five patients had a Gleason grade 7 adenocarcinoma, thirteen had Gleason grade 6 adenocarcinoma, and in four the Gleason grade was unknown. Thirteen patients (39%) received hormonal therapy prior to, and during, radiotherapy. Thirty-two patients received a total radiation dose of 6300-7560 cGy at 180-200 cGy per day. One patient was treated with split course radiotherapy to a dose of 5500 cGy in 22 fractions. Results: Radiotherapy was well tolerated in all patients and there were no unusual or prolonged interruptions in therapy. Nineteen patients (57.6%) are alive 23-98 months from completion of radiotherapy. Thirteen patients are alive free of disease 23-83 months (median 47 months) and six patients are alive with evidence of progression (elevation in PSA) 44-98 months. Fourteen patients died 2-138 months from completion of radiotherapy. Five died without any evidence of disease at 16-138 months. Four patients definitely died with progressive prostate cancer at 11-27 months and in five patients the status of disease at death, 2-103 months, was unknown. The actuarial overall survival at five years was 60.8%. Conclusion: Elderly patients, over 80 years of age, with prostate cancer tolerate prostate irradiation well. The overall survival of 60.8% at 5 years suggests that the elderly patient with a good performance status be strongly considered for high dose prostate irradiation.       Questions about this event email: deutschm@msx.upmc.edu

Cite This Abstract

Deutsch MD, M, Heaton MD, D, Rosenstein MD, M, External Beam Radiotherapy as Treatment for Primary Prostate Cancer in Very Elderly Patients.  Radiological Society of North America 2003 Scientific Assembly and Annual Meeting, November 30 - December 5, 2003 ,Chicago IL. http://archive.rsna.org/2003/3102755.html