The Treatment of Submucosal Uterine Fibroids by Using Magnetic Resonance-Guided Focused Ultrasound Surgery (MRgFUS): The Evaluation of Efficacy and Safety in 3-Year Prospective Study

Participants
Flavia Cobianchi Bellisari, MD, Laquila , Italy (Presenter) Nothing to Disclose
Sonia Iafrate, Laquila, Italy (Abstract Co-Author) Nothing to Disclose
Ilaria Capretti, Laquila, Italy (Abstract Co-Author) Nothing to Disclose
Ester Cannizzaro, MD, L'Aquila, Italy (Abstract Co-Author) Nothing to Disclose
Federica de Matteis, Laquila , Italy (Abstract Co-Author) Nothing to Disclose
Francesco Arrigoni, L'Aquila , Italy (Abstract Co-Author) Nothing to Disclose
Margherita Di Luzio, L'Aquila, Italy (Abstract Co-Author) Nothing to Disclose
Sara Mascaretti, Laquila , Italy (Abstract Co-Author) Nothing to Disclose
Carlo Masciocchi, MD, L'Aquila, Italy (Abstract Co-Author) Nothing to Disclose

For information about this presentation, contact:

sonia.iafrate87@gmail.com

PURPOSE

This study aimed to evaluate clinical efficacy and safety of Magnetic Resonance-guided Focused Ultrasound (MRgFUS) in the treatment of sub-mucosal uterine fibroids in a 3-year prospective study

METHOD AND MATERIALS

Twenty patients affected by sub-mucosal uterine fibroids were treated by MRgFUS (age range 23-54 years), from December 2013 to January 2016. The patients were studied with MRI and classified according to the FIGO staging system. Non-perfused volumes (NPVs) were measured immediately after MRgFUS to calculate the treated area on the c.e. T1-weighed sequences (MRI). The Uterine Fibroid Symptoms and Quality of Life Questionnaire (UFS-QOL) was used to assess the patients' Symptom Severity Scores (SSS) before and after 3 year post-treatment

RESULTS

After MRgFUS treatment, a mean NPV extension of 90,5 % was observed. At follow-up studies up to 3-year, 9 out of 20 patients showed progressive reduction of the uterine volume with regularization of the uterine wall, 11 out of 20 patients showed significant reduction of fibroid volume (about 87%). Each patient was treated during one session. All the patients reported improvement in the UFS-QOL symptoms severity score, when compared with the pre-treatment score. No severe adverse events were observed

CONCLUSION

The results obtained from this study showed that MRgFUS could be safely and effectively used to ablate sub-mucosal uterine fibroids and to improve clinical symptomatology and morphology of uterus

CLINICAL RELEVANCE/APPLICATION

Efficacy and safety of MRgFUS

Abstract Archives of the RSNA, 2019