RSNA 2018

Abstract Archives of the RSNA, 2018


Effect of Artificial Intelligence Based Vessel Suppression and Automatic Detection of Part-Solid and Ground-Glass Nodules on Low-Dose Chest CT

Tuesday, Nov. 27 11:00AM - 11:10AM Room: S504AB

Student Travel Stipend Award

Ramandeep Singh, MBBS, Boston, MA (Presenter) Nothing to Disclose
Chayanin Nitiwarangkul, MD, Boston, MA (Abstract Co-Author) Nothing to Disclose
Jo-Anne O. Shepard, MD, Boston, MA (Abstract Co-Author) Nothing to Disclose
Fatemeh Homayounieh, MD, Chelsea, MA (Abstract Co-Author) Nothing to Disclose
Atul Padole, MD, Boston, MA (Abstract Co-Author) Nothing to Disclose
Shaunagh McDermott, FFR(RCSI), Boston, MA (Abstract Co-Author) Nothing to Disclose
Mannudeep K. Kalra, MD, Boston, MA (Abstract Co-Author) Research Grant, Siemens AG; Research Grant, Canon Medical Systems Corporation
Subba R. Digumarthy, MD, Boston, MA (Abstract Co-Author) Nothing to Disclose
Brent Little, MD, Boston, MA (Abstract Co-Author) Author, Reed Elsevier; Editor, Reed Elsevier


Most studies with CAD and artificial intelligence (AI) software have focused on solid lung nodules. We assessed the effect of AI-based vessel suppression (AI-VS) and automatic detection (AI-AD) on ground glass (GGN) and part-solid lung nodules (PSN) in low-dose CT (LDCT).


Our study included 100 LDCT examinations with mixed attenuation pulmonary nodules (average diameter>5mm) identified from the National Lung Cancer Screening Trial (NLST). These exams were not used in training or validation of the AI software (ClearRead CT, Riverain Inc.). All 100 LDCT were processed to generate three image series per case - unprocessed, AI-VS, and AI-AD series with annotated lung nodules. Two thoracic radiologists (R1: 3-year experience, R2: 27-year experience) independently assessed the unprocessed images alone, then together with AI-VS series, and finally with AI-AD. For each assessment, number of all > 5mm with location & size of dominant GGN and PSN were recorded. Descriptive statistics and student t tests were performed for data analysis.


On unprocessed images, R1 and R2 detected 278 nodules (123 PSN, 155 GGN) and 269 (117 PSN, 152 GGN), respectively (p>0.05). With addition of AI-VS images, R1 and R2 detected 290 nodules (126 PSN, 164 SSN) and 293 (132 PSN, 161 GGN), respectively, which were significantly greater than those detected without the AI-VS (p= 0.004). AI-VS aided in detection of solid component in 22 PSN which were deemed SSN by both readers. Conversely, AI-AD annotated only 75 PSN and 54 GGN (total 129 nodules). In 21 patients, AI-AD did not detect the dominant PSN or SSN; it detected 14 false positive nodules (vessels, atelectasis, anterior junctional line). Average respective sizes of 69-matched and detected PSN on unprocessed and AI-AD series were 15 7 mm and 13 6 mm (p =0.07).


AI-VS improves detection and characterization of GGN and PSN on LDCT of the chest. Specifically, improved and easier detection of the solid component in non-solid nodules with AI-VS can avoid false down-grading of Lung-RADS category, and thus help in appropriate patient management.


AI software can aid in improved detection and confident detection of ground-glass and part-solid lung nodules on low dose chest CT.

Honored Educators

Presenters or authors on this event have been recognized as RSNA Honored Educators for participating in multiple qualifying educational activities. Honored Educators are invested in furthering the profession of radiology by delivering high-quality educational content in their field of study. Learn how you can become an honored educator by visiting the website at: Subba R. Digumarthy, MD - 2013 Honored EducatorBrent Little, MD - 2018 Honored Educator