This is a prospective IRB approved trial recruiting asymptomatic women scheduled for a screening mammogram and WBUS within 30 days of one another. Once accrued to the trial, a CEDM was performed in place of the screening mammogram. Between December, 2014 – March, 2016, 126 women enrolled. The CEDM and WBUS were performed at the same visit and interpreted independently by 2 radiologists blinded to the other modality. For the CEDM, the low dose 2D FFDM images were first interpreted alone prior to being given the contrast-enhanced images. Once final recommendations for each modality were recorded, the patient was managed per standard institutional practice after integrating findings of both studies. For indeterminate findings seen on the contrast-enhanced images of the CEDM but not the low dose 2D or targeted ultrasound, an MRI was performed for further evaluation. If no suspicious correlate was present on the MRI, a 6 month follow up CEDM was recommended. The cancer detection rate (CDR), number of work ups generated for findings seen only on the contrast-enahnced images alone, and the PPV3 of biopsy were determined. Risk factors (breast density, family history (FH), personal history (PH), BRCA status, prior high risk lesion) were recorded.