RSNA 2015

Abstract Archives of the RSNA, 2015


Feasibility Of Improving Detection Of Early Ischemic Infarction on Head CT Using Continuity-Based Correlative Enhancement.

Tuesday, Dec. 1 8:55AM - 9:05AM Location: N230

Aseem Sharma, MBBS, Saint Louis, MO (Presenter) Stockholder, General Electric Company; Consultant, BioMedical Systems; Co-Founder, Correlative Enhancement, LLC
Manu S. Goyal, MD, MSc, Saint Louis, MO (Abstract Co-Author) Nothing to Disclose
Michelle M. Miller-Thomas, MD, Saint Louis, MO (Abstract Co-Author) Nothing to Disclose
Rashmi Jain, MD, Saint Louis, MO (Abstract Co-Author) Nothing to Disclose
James D. McEachern, MD, Saskatoon, SK (Abstract Co-Author) Nothing to Disclose
Charles F. Hildebolt, DDS, PhD, Saint Louis, MO (Abstract Co-Author) Nothing to Disclose

Recognition of early signs of brain infarction may influence patient management, but can be difficult on head CT. Using custom software (patent pending) that manipulates images based on correlation between intensities of continuous pixels, we aimed to assess the feasibility of improving the detection of brain infarction with head CT images.


35 head CT images through the region of proven infarction and 20 control images across brain tissue without infarction were post-processed using a custom software (patent pending). Three readers, evaluated the baseline and enhanced images in a masked manner, and marked the location of infarction whenever suspected, while using a 5-point scale to rate their confidence for the presence of infarction. In a separate session, readers rated the comparative ease-of-recognition of signs of infarction for baseline and enhanced images on a 7-point scale, while evaluating these images simultaneously along with the follow-up imaging indicating the infarct distribution. Infarct identification data were analyzed with jackknife, alternative, free-response receiver operating characteristic (JAFROC) weighted software. Comparative ease-of-recognition was assessed using the one-sided Wilcoxon signed rank test for differences > a value of 4.


For infarct localization, JAFROC analysis revealed figure-of-merit values of 0.56 and 0.67 for baseline and enhance images respectively (p=0.03). Corresponding values for infarct localization within 6 hours of symptom onset were 0.49 and 0.63 (p = 0.04). Comparative ease-of-recognition was significantly higher than the equivalent value of 4 for all three readers (p <0.01, 0.03, <0.01), tilted favorably towards the enhanced images.


Continuity-based correlative enhancement improves conspicuity and accurate detection of early changes of brain infarction on non-contrasted head CT.


By improving diagnostic accuracy for detection of ischemic infarction on head CT, continuity-based correlative enhancement may help in making more informed decisions for management of stroke patients.