Nicola Galea MD, Abstract Co-Author: Nothing to Disclose

Marco Francone MD, Abstract Co-Author: Speakers Bureau, Bracco nv

Valentina Sorrentino, Abstract Co-Author: Nothing to Disclose

Vincenzo Noce MD, Abstract Co-Author: Nothing to Disclose

Giovanni Barchetti, Abstract Co-Author: Nothing to Disclose

Giuseppe Cannavale MD, Abstract Co-Author: Nothing to Disclose

Iacopo Carbone MD, Presenter: Nothing to Disclose

Carlo Catalano MD, Abstract Co-Author: Nothing to Disclose

Non-compaction cardiomyopathy (NCC) is characterized by uncompleted myocardial compaction. Our purpose was to correlate the morphological features of NCC with the impairment of left ventricular (LV) contractile function using Cardiac Magnetic Resonance (CMR).

Fifteen patients with echocardiography diagnosis of NCC perfomed a CMR study using a 1.5T MR unit, cineMR b-SSFP and late enhancement (LE) sequences after Gadobenate dimeglumine administration. Compacted myocardial mass (CMM), non-compacted myocardial mass (NCMM), non-compacted to compacted myocardial mass ratio (NC/C mass ratio), non-compacted to compacted myocardial thickness ratio (NC/C ratio), number of affected LV segments (nNC) were analysed and correlated to left ventricular volumes, ejection fraction (EF), peak filling rate (PFR) and peak ejection rate (PER). Pearson correlation test was performed.

The mean values of NC/C mass ratio, NC/C ratio and number of affected segments were respectively 0.4, 2.6 and 9.9. No significant correlations were found between NC/C mass ratio both PER (p: 0.10), FE (p: 0.15) and PFR (p: 0.25), and between nNC and PER (p: 0.14). NC/C ratio showed no significant correlation with PER (p: 0.21), FE (p:0.54) and PFR (p: 0.17).

In NCC contractile dysfunction entity, espressed by reduction of PER and EF, is not directly related to the increase of NC/C ratio or with changes in NC/C mass ratio. Further index of structural abnormality should be considered to characterize disease severity.

The current diagnostic criteria for "non-compaction cardiomyopathy" determine an overdiagnosis of this still poor understood disease with an increasing alarm in subjects with one of the non-pathological anatomical variants. According to our results the increase of structural morphological alteration does not cause "per se" higher degree of functional impairment, therefore the diagnostic criteria should be further discussed.

Galea, N, Francone, M, Sorrentino, V, Noce, V, Barchetti, G, Cannavale, G, Carbone, I, Catalano, C, Noncompaction Cardiomyopathy: Left Ventricular Systolic Dysfunction is not Correlated to Non-compacted Myocardium Extent on Cardiac Magnetic Resonance.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14045789.html