Jong Hyouk Yun MD, Presenter: Nothing to Disclose

Jung Gu Park, Abstract Co-Author: Nothing to Disclose

Hee Kang MD, Abstract Co-Author: Nothing to Disclose

The aim of this study is to evaluate the prognosis of nonresectable cholangiolocellular carcinoma compared with conventional mass-forming intrahepatic cholangiocarcinoma and associated multiphasic CT findings

From January, 2007 to December, 2013, we retrospectively studied 82 patients with pathologically confirmed nonresectable MF type ICC. Prognosis was compared between 14 patients with cholangiolocellular carcinoma and 68 patients with conventional intrahepatic MF cholangiocarcinoma. Multiphasic liver CT images were evaluated for tumor morphology and enhancement features. Survival rates of two groups were calculated by using the Kaplan-meier method, and the differences in survival were compared by using the log-rank test. A Cox proportional hazard model was used for multivariate survival analysis

Hypervascular masses were shown in twelve (85%) of 14 cholangiolocellular carcinoma and twelve (17%) of 68 conventional MF type ICCs. The mean diameter of cholangiolocellular carcinoma was significantly smaller than that of conventional MF type ICCs (P=0.025). The median patient survival period of cholangiolocellular carcinoma was significantly longer than conventional MF type ICCs (P= 0.04). Results of multivariable Cox regression analyses confirmed that tumor size (hazard ratio [HR], 1.08; P=0.02), hypovascular tumor (HR, 2.01; P=0.001), and metastatic lymphadenopthy (HR, 2.90; P=0.01) were the independent factors associated with patient survival duration

The cholangiolocellular carcinoma seems to be better prognosis compared with conventional MF type ICCs. The patient survival of MF type ICCs is significantly dependent on tumor size, tumor vascularity and metastatic lymphadenopathy.

The cholangiolocellular carcinoma seems to be better prognosis compared with conventional MF type ICCs.

Yun, J, Park, J, Kang, H, Cholangiolocellular Carcinoma vs. Conventional Mass-Forming Intrahepatic Cholangiocarcinoma: Comparison of Prognosis and Multiphasic CT Finding.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14045750.html