Masashi Takahashi RT, Presenter: Nothing to Disclose

naohiro yamagami, Abstract Co-Author: Nothing to Disclose

Satoshi Inada, Abstract Co-Author: Nothing to Disclose

Yue Dong, Abstract Co-Author: Nothing to Disclose

Hironori Ueda, Abstract Co-Author: Nothing to Disclose

Yoshio Monzen MD, Abstract Co-Author: Nothing to Disclose

Fractional flow reserve (FFR) is a standard method, which give us physiological information about coronary artery disease with invasive methods. On the other hand, a new technology Fractional flow reserve computer tomography (FFRCT) by using Coronary CT angiography (CTA) can provide FFR without invasive methods. The accuracy, reliability, and feasibility for clinical application of FFR are evaluated in this study.

Eight phantom models made of ABS resins with different ratio of stenosis underwent CT scan. And the three-dimensional datasets of phantoms obtained by CT scan were generated, and were analyzed by the CFD Software.The threshold for VR model was calculated by FWHM of CT value generated from profile curve on 2D image. On the liquid flowing phantom models, we compared FFRCT value from CFD software and actual measured value calculated by Pressure-Wire, in order to evaluate the accuracy of FFRCT value. Moreover, we examined hemodynamic by using Velocity, Pressure and WSS( stands for Wall shear stress, and relative to vascular events) generated by CFD analysis.

In FFR and FFRCT, an approximately equal value was provided.WSS and pressure decreased with the same rate range on the tandem lesion model which possessed two same stenosis. However, on the tandem lesion model with proximal severe stenosis, the influence of distal stenosis for whole tube WSS was small. FFR calculated from pressure wire can only evaluate the change of Pressure, however CFD analysis can observe and visualize Pressure, WSS, and Velocity.

FFRCT by CFD analysis is useful and it could be a standard evaluation tool for optimal PCI. The information of Pressure, WSS and Velocity could assess the hemodynamics of coronary artery and were useful to build a strategy for optimal PCI on complex lesions. Moreover, the FFRCT could predict the prognosis of coronary artery disease and be a non-invasive follow up tool after PCI.  

FFRCT by CFD will be useful application for coronal cardiac diagnosis.

Takahashi, M, yamagami, n, Inada, S, Dong, Y, Ueda, H, Monzen, Y, Analysis of FFRCT and Blood Flow using CFD Software.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14045741.html