Nicholas J. Screaton BMBCh, Abstract Co-Author: Nothing to Disclose

Thida Win, Abstract Co-Author: Nothing to Disclose

Joanna C. Porter PhD, FRCP, Abstract Co-Author: Advisor, Onyx Pharmaceuticals, Inc Advisor, InterMune, Inc

Lynn Millner, Abstract Co-Author: Research funded, GlaxoSmithKline plc

Francesco Fraioli MD, Presenter: Nothing to Disclose

Ashley McAllister Groves MBBS, Abstract Co-Author: Investigator, GlaxoSmithKline plc Investigator, General Electric Company Investigator, Siemens AG

Noninvasive markers of disease activity in diffuse parenchymal lung disease (DPLD) are lacking, which is delaying the end points for clinical trials. We investigate the potential of 18F-FDG-PET/CT to assess disease activity and monitor treatment response in DPLD patients with mixed reticular ground glass changes on high resolution computed tomography (HRCT).

Twenty-one patients (11-male, 10-female, mean age 68±11) with DPLD were prospectively recruited. Two patients had biopsy proven non-specific interstitial pneumonia (NSIP). The other 19-patients had mixed interstitial inflammation and fibrosis consistent with NSIP following multidisciplinary review on the basis of clinical, pulmonary function tests (PFTs) and HRCT. PFTs and thoracic 18FDG-PET/CT were performed pre and post-treatment. Pulmonary FDG uptake (SUVmax) was calculated pre and post-treatment.

Changes in pulmonary SUVmax correlated with pulmonary function changes post-treatment (FEV1 r=-0.60, p=0.004; FVC r=-0.65, p=0.001; TLco r=-0.65, p=0.004). In addition, pretreatment SUVmax correlated with post treatment SUVmax (r= 0.51, p=0.019).

18FDG-PET/CT has potential as a biomarker in patients with DPLD with a mixed reticular ground-glass HRCT appearance

18FDG PET/CT has potential to monitor treatment response in patients with NSIP

Screaton, N, Win, T, Porter, J, Millner, L, Fraioli, F, Groves, A, Changes in Pulmonary 18F-FDG PET Uptake Reflect Treatment Response in Patients with Diffuse Parenchymal Lung Disease.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14045663.html